Results 71 to 80 of about 118,363 (344)

Recent perspectives on the synergy of mesenchymal stem cells with micro/nano strategies in peripheral nerve regeneration-a review

Frontiers in Bioengineering and Biotechnology
Despite the intrinsic repair of peripheral nerve injury (PNI), it is important to carefully monitor the process of peripheral nerve repair, as peripheral nerve regeneration is slow and incomplete in large traumatic lesions. Hence, mesenchymal stem cells (
Majid Sharifi, Majid Sharifi, Majid Sharifi, Mohammad Kamalabadi-Farahani, Mohammad Kamalabadi-Farahani, Majid Salehi, Majid Salehi, Majid Salehi, Somayeh Ebrahimi-Brough, Morteza Alizadeh   +9 more
doaj   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Electrical aligned polyurethane nerve guidance conduit modulates macrophage polarization and facilitates immunoregulatory peripheral nerve regeneration

Journal of Nanobiotechnology
Biomaterials can modulate the local immune microenvironments to promote peripheral nerve regeneration. Inspired by the spatial orderly distribution and endogenous electric field of nerve fibers, we aimed to investigate the synergistic effects of ...
Yiting Sun, Yinglong Zhang, Yibo Guo, Dongming He, Wanlin Xu, Wei Fang, Chenping Zhang, Yi Zuo, Zhen Zhang   +8 more
doaj   +1 more source

Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair

International Journal of Extreme Manufacturing, 2023
Because of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory.
Juqing Song, Baiheng Lv, Wencong Chen, Peng Ding, Yong He   +4 more
doaj   +1 more source

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]

, 2015
Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky, Demon, Dieter, Janssens, Sophie, Lamkanfi, Mohamed, Lornet, Guillaume, Timmerman, Vincent, Ydens, Elke   +6 more
core   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Iron role paradox in nerve degeneration and regeneration

Physiological Reports
Iron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de‐differentiation.
Samira Bolandghamat, Morteza Behnam‐Rassouli   +1 more
doaj   +1 more source

Fas ligand regulate nerve injury and repair by affecting AKT, β-catenin, and NF-κB pathways

IBRO Neuroscience Reports
Objective: To investigate the regulatory effect of Fas-L on the repair and regeneration of peripheral extension injury in rats. Methods: This study aimed to explore the effects of Fas-L on apoptosis and axonal regeneration of dorsal root ganglion (DRG ...
Yiyue Zhou, Yi Yao, Yumei Feng, Zhiyuan Qiu, Shixian Luo, Xinyu Shi, Dandan Gu, Maorong Jiang, Min Cai, Dengbing Yao   +9 more
doaj   +1 more source

Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. [PDF]

, 2017
The therapeutic benefit of cell transplantation has been assessed in a host of central nervous system (CNS) diseases, including disorders of the spinal cord such as traumatic spinal cord injury (SCI).
Charsar, Brittany A., Lepore, Angelo C., Urban, Mark W.   +2 more
core   +2 more sources