Results 31 to 40 of about 1,715,266 (244)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Transcutaneous vagus nerve stimulation: retrospective assessment of cardiac safety in a pilot study. [PDF]

, 2012
Background: Vagus nerve stimulation has been successfully used as a treatment strategy for epilepsy and affective disorders for years. Transcutaneous vagus nerve stimulation (tVNS) is a new non-invasive method to stimulate the vagus nerve, which has been
Berthold Langguth, Michael Landgrebe, Prasser, Sarah Julia, Martin Schecklmann, Michael eLandgrebe, Resch, Markus, Markus eResch, Martin eSchecklmann, Florian eGeisreiter, Goeran eHajak, Landgrebe, Michael, Markus Resch, Hajak, Göran, Langguth, Berthold, Timm B Poeppl, Berthold eLangguth, Sarah Julia Prasser, Schecklmann, Martin, Kreuzer, Peter M., Oliver eHusser, Timm B. Poeppl, Husser, Oliver, Peter M. Kreuzer, Oliver Husser, Geisreiter, Florian, Peter Michael Kreuzer, Goeran Hajak, Poeppl, Timm B., Florian Geisreiter   +28 more
core   +1 more source

An improvised indigenous technique for nerve stimulation-assisted peripheral nerve blocks

Saudi Journal of Anaesthesia, 2012
Regional anesthesia is one of the most satisfying expertise in anesthesia. Nerve stimulation guided peripheral nerve blocks greatly enhance the success rate of block.
Anuj Jain, Surendra Singh
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Birds of a Feather Redux: Defining Ways to Stimulate the Peripheral Nervous System

Journal of Pain Research, 2023
Timothy Deer,1 Anuj Shah,2 Konstantin Slavin,3 Kevin E Vorenkamp,4 Shalini Shah,5 Michael Leong,6 W Porter McRoberts7 1The Spine and Nerve Center of the Virginias, Charleston, WV, USA; 2Department of Physical Medicine and Rehabilitation, Detroit Medical ...
Deer T, Shah A, Slavin K, Vorenkamp KE, Shah S, Leong M, McRoberts WP   +6 more
doaj  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Unmasking of latent synaptic connections in the cortex of the rat, elicited by a facial nerve transection [PDF]

, 2001
Peripheral nerve injury elicits plastic changes in the cortex, resulting in reorganization of the somatotopic representation maps. These processes begin within minutes after nerve injury, and last for weeks.
Toldi, József, Toldi József, Farkas, Tamás, Farkas Tamás   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Table_1_Electrical stimulation therapy for peripheral nerve injury.XLSX

, 2023
Peripheral nerve injury is common and frequently occurs in extremity trauma patients. The motor and sensory impairment caused by the injury will affect patients' daily life and social work. Surgical therapeutic approaches don't assure functional recovery,
Zuobing Chen (11454019), Zhao Yao (4707211), Lingmei Ni (10721059), Siyue Li (275761), Yifan Zhao (659636), Jie Wang (16762), Tianfang Zhang (801906)   +6 more
core   +1 more source