Results 221 to 230 of about 173,877 (309)

CTBPro: A Next‐Generation Cholera Toxin Subunit B‐Based Neuroanatomical Tracer With Superior Brightness, Stability, and Sensitivity for Enhanced Neural Circuit Mapping

Advanced Science, EarlyView.
CTBPro is a next‐generation cholera toxin B–based tracer engineered by fusing CTB to the ultra‐stable fluorescent protein mBaojin. Exhibiting markedly enhanced molar brightness, CTBPro enables high‐fidelity neuronal labeling across multiple administration routes.
Xinghua Quan, Yude Lou, Huiqi Xie, Yifei Wang, Yanzhe Zhang, Yiran Ge, Linhe Yang, Xiaoxuan Zhang, Qingmiao Zhou, Huaizong Shen, Longxing Cao, Xin Jin, Jie‐Min Jia   +12 more
wiley   +1 more source

Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy. [PDF]

J Neuroinflammation
Chan ACY, Huang H, Shah A, Zhang B, Foo NWJ, Li R, Mohammad Rizal NAB, Wong HY, Teoh HL, Mak A, Soong TW, Sharma VK, Schwarz H.   +12 more
europepmc   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

The Potential Role of Adipose-Derived Stem Cells in Regeneration of Peripheral Nerves. [PDF]

Neurol Int
Mohan SP, Priya SP, Tawfig N, Padmanabhan V, Babiker R, Palaniappan A, Prabhu S, Chaitanya NC, Rahman MM, Islam MS.   +9 more
europepmc   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy. [PDF]

Mol Ther Methods Clin Dev
Grubor B, Henry KL, Chan SJ, Sheehan M, Shah A, Pellerin A, Bai J, Nadella P, Bommegowda S, Cullen P, Tien E, Chen V, van der Munnik NP, White-Hunt S, Plowey ED, Hamann S, Guise AJ, Xu S, Kirkland M, Doherty J, Lyashenko E, Bhat G, Glajch K, Lo SC, Gianni D, Clarner P, Gagnon J, Chu J, Nambiar K, Lulla M, Zheng F, Weldeab A, Bartlett D, Gutnick A, Reynolds T, Zhu K, Huh D, Carlile TM, Fikes J, Trapa P, Suh J, Morris D, Burkly L.   +42 more
europepmc   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Repair methods in peripheral nerves after traumatic injuries: a systematic literature review. [PDF]

Acta Cir Bras
Costa NN, Santos JFD, Aranha MFAC, Coelho EWF, Paes VLS, Oliveira RCS.   +5 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Brain Nuclei in the Regulation of Sexual Behavior, Peripheral Nerves Related to Reproduction, and Their Alterations in Neurodegenerative Diseases: A Brief Review. [PDF]

Brain Sci
Palacios-Arellano MP, Landa-García JN, García-Martínez ED, Manzo-Denes J, Aranda-Abreu GE, Rojas-Durán F, Herrera-Covarrubias D, Toledo-Cárdenas MR, Coria-Ávila GA, Suárez-Medellín JM, Pérez-Estudillo CA, Hernández-Aguilar ME.   +11 more
europepmc   +1 more source