Results 251 to 260 of about 162,242 (310)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Managing Major Peripheral Nerves in Forearm-Level Amputations With TMR and RPNI: What's the Best Recipe? [PDF]

Hand (N Y)
Rees AB, Mastracci JC, Posey SL, Loeffler BJ, Gaston RG.   +4 more
europepmc   +1 more source

Effect of traction force during surgery on physical integrity and histologicalchanges in peripheral nerves: experimental study on rabbits

Rebwar Hassan Mohammed, Khurshid A Kheder Khrwatany, Snur Hassan   +2 more
openalex   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system. [PDF]

Sci Adv
Ligocki AP, Vinson AV, Yachnis AT, Dunn WA, Smith DE, Scott EA, Alvarez-Castanon JV, Baez Montalvo DE, Frisone OG, Brown GAJ, Pessa JE, Scott EW.   +11 more
europepmc   +1 more source

Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice. [PDF]

JBMR Plus
Beeve AT, Hassan MG, Li A, Migotsky N, Silva MJ, Scheller EL.   +5 more
europepmc   +1 more source

Correction: Arriero-Cabañero et al. Transplantation of Predegenerated Peripheral Nerves after Complete Spinal Cord Transection in Rats: Effect of Neural Precursor Cells and Pharmacological Treatment with the Sulfoglycolipid Tol-51. <i>Cells</i> 2024, <i>13</i>, 1324. [PDF]

Cells
Arriero-Cabañero A, García-Vences E, Sánchez-Torres S, Aristizabal-Hernandez S, García-Rama C, Pérez-Rizo E, Fernández-Mayoralas A, Grijalva I, Buzoianu-Anguiano V, Doncel-Pérez E, Mey J.   +10 more
europepmc   +1 more source

Biomechanical modelling infers that collagen content within peripheral nerves is a greater indicator of axial Young's modulus than structure. [PDF]

Biomech Model Mechanobiol
Doman EA, Ovenden NC, Phillips JB, Shipley RJ.   +3 more
europepmc   +1 more source

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Peripheral nerve repair

International Rehabilitation Medicine, 1981
The neuron is remarkable as a cell with a prolonged process, the axon. Various substances and organelles are transported up and down the axon. Axotomy profoundly affects this axonal transport. The proximal stump of the axon seals off and organelles accumulate. Terminal sprouts appear and move towards the distal stump.
K, Kristensson, T, Olsson
openaire   +2 more sources

Peripheral Nerve Regeneration

Annual Review of Neuroscience, 1990
Schwann cell basal laminae were demonstrated to serve as efficient conduits for the growth of regenerating axons in frozen nerve grafts, and in in situ freezing experiments. Regenerating axonal sprouts usually emanated from the first node of Ranvier proximal to the site of damage, and grew out along the inner surface of the basal lamina.
J W, Fawcett, R J, Keynes
openaire   +4 more sources