Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]
, 2016 The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi +51 more
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Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
core +3 more sources
What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]
, 2018 Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
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A rare cause of peripheral facial paralysis in childhood in our country: lyme disease [PDF]
, 2017 Lyme disease is a zoonosis caused by Spirochetes called Borrelia burgdorferi, involving several areas, such as the skin, heart and central nervous system.
Gürses, Dolunay, Özdemir, Emine
core +2 more sources
Muscarinic receptor oligomerization [PDF]
, 2018 G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa +3 more
core +1 more source
Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair [PDF]
, 2016 Peripheral nerve injury continues to pose a clinical hurdle despite its frequency and advances in treatment. Unlike the central nervous system, neurons of the peripheral nervous system have a greater ability to regenerate.
Bhangra, KS +3 more
core +4 more sources
Rapid testing leads to the underestimation of the scrapie prevalence in an affected sheep and goat flock [PDF]
, 2007 To obtain a more detailed understanding of the prevalence of classical scrapie infections in a heavily affected German sheep flock (composed of 603 sheep and 6 goats), we analysed 169 sheep and 6 goats that carried the genotypes susceptible to the ...
Bellmann, Steffi +10 more
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Peripheral nervous system involvement in multiple sclerosis [PDF]
, 2011 Fragestellung: Gibt es eine subklinische Beteiligung des peripheren Nervensystems bei Patienten mit Multipler Sklerose (MS) i) im Bereich der schnell leitenden Aα- und β-Fasern und/oder ii) im Bereich der langsam leitenden Aδ-Fasern?
Gartzen, Kristina
core +1 more source
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
, 2006 BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore +7 more
core +3 more sources
The Peripheral Nervous System☆
, 2007 openAccessArticle: False ; cover date: 2015-01-01 ; pii: B978-0-12-801238-3.05360-5 ; Harvest Date: 2016-01-06 13:08:10 ; issueName: ; Page Range: - ; href scidir: http://www.sciencedirect.com/science/article/pii/B9780128012383053605 ; pubType:
J., Cuevas, Cuevas, J.
openaire +2 more sources