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Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021 : a systematic analysis for the Global Burden of Disease Study 2021
: Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19.Alemi, Sharifullah, Hall, Brian J, Servili, Chiara, Behnam, Babak, Anwer, Razique, Glasstetter, Logan M, Garg, Naval, Baran, Mehmet Firat, Dejene, Hiwot, Hareru, Habtamu Endashaw, Agyemang-Duah, Williams, Fatima, Syeda Anum Fatima, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Deng, Xinlei, Abdullahi, Auwal, Abelda\uf1o Zu\uf1iga, Roberto Ariel, Haile, Teklehaimanot Gereziher, Hamiduzzaman, Mohammad, Bj\uf8rge, Tone, Alahdab, Fares, Akonde, Maxwell, Gebre, Teshome, Hassan, Shoaib, Hassen, Mohammed Bheser, Abdulah, Deldar Morad, Alif, Sheikh Mohammad, Das, Saswati, Amzat, Jimoh, Bustanji, Yasser, Boloor, Archith, Ding, Delaney D, Fonseca, Ana Catarina, Beiranvand, Maryam, Cegolon, Luca, Darwish, Amira Hamed, Arafat, Mosab, Hoffman, Howard J, Al-Omari, Basem, Abdollahi, Mohammad, Abd-Rabu, Rami, Elilo, Legesse Tesfaye, Artanti, Kurnia Dwi, AL-Ahdal, Tareq Mohammed Ali, Bikbov, Boris, Fukumoto, Takeshi, Ghozy, Sherief, Aliyi, Ahmednur Adem, Ghasemi, MohammadReza, Guan, Bin, Ali, Abid, Charan, Jaykaran, Hegazy, Mohamed I, Carabin, H\ue9l\ue8ne, Adekanmbi, Victor, Dhama, Kuldeep, Afzal, Saira, Hasanian, Mohammad, Bhatti, Jasvinder Singh, Chu, Dinh-Toi, Catapano, Alberico L, Galali, Yaseen, De Leo, Diego, Aboyans, Victor, Ahmed, Ayman, Cousin, Ewerton, Agodi, Antonella, B\ue4rnighausen, Till Winfried, Banach, Maciej, Ali, Zahid, Gebrehiwot, Mesfin, Atorkey, Prince, Azadnajafabad, Sina, Aruleba, Raphael Taiwo, Hannan, Md. Abdul, Beyene, Kebede A, Amindarolzarbi, Alireza, Arooj, Mahwish, Bettencourt, Paulo J G, Hosseinzadeh, Mehdi, Gupta, Veer Bala, Bandyopadhyay, Soham, Desai, Hardik Dineshbhai, Ahmed, Muktar Beshir, Getacher, Lemma, Fadaei, Abdolmajid, Butt, Nadeem Shafique, Hagins, Hailey, Ahmad, Aqeel, Catal\ue1-L\uf3pez, Ferr\ue1n, Dube, John, Aljunid, Syed Mohamed, Abiodun, Olumide, Habibzadeh, Farrokh, Ahmed, Syed Anees, Alqasmi, Ibrahim, Gill, Paramjit Singh, Heidari, Golnaz, Holla, Ramesh, Faro, Andre, Algammal, Abdelazeem M, Atout, Maha Moh'd Wahbi, Dziedzic, Arkadiusz Marian, Eskandarieh, Sharareh, Haep, Nils, Demetriades, Andreas K, Ali, Syed Shujait Shujait, Akbarialiabad, Hossein, Azzam, Ahmed Y, Goleij, Pouya, Al-Tawfiq, Jaffar A, Ghazy, Ramy Mohamed, Abbas, Jaffar, Fornari, Arianna, Dandona, Lalit, Abbasi, Madineh Akram, Feizkhah, Alireza, Alqahtani, Jaber S, Artamonov, Anton A, Do, Thanh Chi, AlBataineh, Mohammad T, Emamverdi, Mehdi, Campos-Nonato, Ismael R, Abidi, Hassan, Basso, Jo\ue3o Diogo, Caye, Arthur, Gardner, William M, Batiha, Abdul-Monim Mohammad, Ahmad, Danish, Fereshtehnejad, Seyed-Mohammad, Aljofan, Mohamad, De la Hoz, Fernando Pio, Baghdadi, Soroush, Balalla, Shivanthi, Aji, Budi, Burns, Richard A, Brown, Julie, Chi, Gerald, Chung, Eric, Dhimal, Meghnath, Eissazade, Negin, Diress, Mengistie, Hosseinzadeh, Hassan, Berice, Betyna, Ekundayo, Temitope Cyrus, Baig, Atif Amin, Dharmaratne, Samath Dhamminda, Dehghan, Amin, Addo, Isaac Yeboah, Alzoubi, Karem H, Bagherieh, Sara, Aly, Hany, Esezobor, Christopher Imokhuede, Dongarwar, Deepa, Avan, Abolfazl, Dandona, Rakhi, Heidari, Mohammad, Dadras, Omid, Coberly, Kaleb, Ghotbi, Elena, Gandhi, Aravind P, Cao, Bochen, Nichols, Emma, Babaei, Mahsa, Adamu, Lawan Hassan, Hao, Junwei, Akinosoglou, Karolina, Bensenor, Isabela M, Seeher, Katrin Maria, Abdollahifar, Mohammad-Amin, Al-Gheethi, Adel Ali Saeed, Elgar, Frank J, Ahmed, Luai A, Gunawardane, Damitha Asanga, Ali, Shahid, Ali, Liaqat, Ching, Patrick R, Doan, Khanh Duy Khanh, Dirac, M Ashworth, Gaidhane, Abhay Motiramji, Hezam, Kamal, Asghari-Jafarabadi, Mohammad, Bitaraf, Saeid, Chekol Abebe, Endeshaw, Cortesi, Paolo Angelo, Angappan, Dhanalakshmi, Chowdhury, Enayet Karim, El Nahas, Nevine, Barker-Collo, Suzanne Lyn, Batra, Kavita, Gebremeskel, Gebreamlak Gebremedhn, Hameed, Sajid, Angesom, Teklit W, Chong, Yuen Yu, Goulart, Alessandra C, Barchitta, Martina, Basiru, Afisu, Dias da Silva, Diana, Gautam, Rupesh K, Guicciardi, Stefano, Bhadra, Abhishek, Ayatollahi, Haleh, Guti\ue9rrez, Reyna Alma, Gnedovskaya, Elena V, Harapan, Harapan, Gomes-Neto, Mansueto, Abate, Yohannes Habtegiorgis, Dodangeh, Milad, Guadie, Habtamu Alganeh, Adra, Saryia, Golinelli, Davide, Dash, Nihar Ranjan, Elmeligy, Omar Abdelsadek Abdou, Guarducci, Giovanni, Almazan, Joseph Uy, Bennett, Derrick A, Bemanalizadeh, Maryam, Hassanipour, Soheil, Dascalu, Ana Maria, Ashraf, Muhammad, Aburuz, Salahdein, Heidari-Soureshjani, Reza, Haubold, Johannes, Cruz-Martins, Nat\ue1lia, Dokova, Klara Georgieva, Devanbu, Vinoth Gnana Chellaiyan, Hankey, Graeme J, Aravkin, Aleksandr Y, Bardhan, Mainak, Hopf, Kathleen Pillsbury, Azizi, Zahra, Amiri, Sohrab, Duraisamy, Senbagam, Goyal, Anmol, Carreras, Giulia, Cabral, Lucas Scotta, Ashraf, Tahira, Chen, Hui, Brayne, Carol, Ahinkorah, Bright Opoku, Adebayo, Oladimeji M, Badar, Muhammad, Hammoud, Ahmad, Gray, Richard J, Amusa, Ganiyu Adeniyi, Hasan, Faizul, Braithwaite, Dejana, Bhat, Ajay Nagesh, Haj-Mirzaian, Arvin, Butt, Muhammad Hammad, Balakrishnan, Senthilkumar, Farjoud Kouhanjani, Mohsen, Azizian, Khalil, Horita, Nobuyuki, Mehlman, Max L, Steinmetz, Jaimie D, Arifin, Hidayat, Elgendy, Islam Y, Athari, Seyyed Shamsadin, Conde, Joao, Gau, Shuo-Yan, Hachinski, Vladimir, Bai, Ruhai, Barrow, Amadou, Behnoush, Amir Hossein, Force, Lisa M, Hadei, Mostafa, Comachio, Josielli, Dashti, Mohsen, Amu, Hubert, Fetensa, Getahun, Altaany, Zaid, Atalell, Kendalem Asmare, Abbastabar, Hedayat, Demant, Daniel, Ghimire, Sailaja, Ansari-Moghaddam, Alireza, Adnani, Qorinah Estiningtyas Sakilah, Afolabi, Aanuoluwapo Adeyimika, Fares, Jawad, Anderlini, Deanna, Bhagat, Devidas S, Andrei, Catalina Liliana, Aujayeb, Avinash, Harlianto, Netanja I., Chanie, Gashaw Sisay, Hassan, Amr, Biswas, Atanu, Fischer, Florian, Ahmadzade, Amir Mahmoud, Aly, Safwat, Hadi, Najah R, Hay, Simon I, Abbasian, Mohammadreza, Aboagye, Richard Gyan, Aghamiri, Shahin, Hossain, Md Mahbub, Abolhassani, Hassan, Bhatti, Rajbir, Casulli, Adriano, Criqui, Michael H, Ajami, Marjan, Ayinde, Olatunde O, Bhat, Vivek, Chattu, Vijay Kumar, Carvalho, Andre F, Haro, Josep Maria, Dibas, Mahmoud, Emeto, Theophilus I, Endres, Matthias, Abdollahi, Mozhan, Ali, Endale Alemayehu, Afework, Tsion, Asadi-Pooya, Ali A, Columbus, Alyssa, Demissie, Solomon, Hanifi, Nasrin, Bekele, Alehegn, Foroutan, Behzad, Faramarzi, Ali, Ayala Quintanilla, Beatriz Paulina, Dehghan, Azizallah, Ayyoubzadeh, Seyed Mohammad, Barboza, Miguel A, Chichagi, Fatemeh, Do, Thao Huynh Phuong, Alhalaiqa, Fadwa Alhalaiqa Naji, Bhargava, Ashish, Ellenbogen, Richard G, Alemi, Hediyeh, Altirkawi, Khalid A, Dai, Xiaochen, Alhassan, Robert Kaba, Buonsenso, Danilo, Schiess, Nicoline, Gebreslassie, Haftay Gebremedhin, Abu-Gharbieh, Eman, Chidambaram, Saravana Babu, Ahmed, Jivan Qasim, Ali, Musa Mohammed, Al-Worafi, Yaser Mohammed, Chowdhury, Rajiv, B\ue9jot, Yannick, de la Torre-Luque, Alejandro, Gialluisi, Alessandro, Abrha, Woldu Aberhe, Bitra, Veera R, Dadana, Sriharsha, Bhardwaj, Pankaj, Dinu, Monica, Atreya, Alok, Badiye, Ashish D, Banerjee, Indrajit, Almustanyir, Sami, Gupta, Rajeev, Elsohaby, Ibrahim, Bodunrin, Aadam Olalekan, Ghadirian, Fataneh, Bashash, Davood, Abedi, Aidin, Akhlaghi, Shiva, Dsouza, Haneil Larson, Bringas Vega, Maria L, Budke, Christine M, Belete, Melaku Ashagrie, Moberg, Madeline E, Adikusuma, Wirawan, Cao, Chao, Ganesan, Balasankar, Dutta, Sulagna, Atinafu, Bantalem Tilaye Tilaye, Burkart, Katrin, Chan, Jeffrey Shi Kai, Chukwu, Isaac Sunday, Bodolica, Virginia, Elmonem, Mohamed A, Casta\uf1eda-Orjuela, Carlos A, Cenderadewi, Muthia, Baltatu, Ovidiu Constantin, Abualhasan, Ahmed, Alvis-Guzman, Nelson, Durojaiye, Oyewole Christopher, Han, Hannah, Aldawsari, Khalifah A, Fagbamigbe, Adeniyi Francis, Asena, Tilahun Ferede, Chopra, Hitesh, Areda, Demelash, Ferrari, Alize J, Cavallera, Vanessa, Doheim, Mohamed Fahmy, Chitheer, Abdulaal, Akinyemi, Rufus Olusola, Benfor, Bright, Ajumobi, Olufemi, Bashiru, Hameed Akande, Chen, Jianqi, Hiraike, Yuta, Elemam, Noha Mousaad, Gupta, Sapna, Adekiya, Tayo Alex, Bijani, Ali, Gadanya, Muktar A, Fahim, Ayesha, Farzadfar, Farshad, Amani, Reza, Guo, Hanbing, Hossain, Sahadat, Elbarazi, Iffat, Androudi, Sofia, Ferreira, Nuno, Das, Subasish, Ekholuenetale, Michael, Amirzade-Iranaq, Mohammad Hosein, Gupta, Vivek Kumar, El Sayed, Iman, \uc4rnl\uf6v, Johan, Elahi Najafi, Mohammad Amin, Golchin, Ali, Ahmed, Haroon, Calina, Daniela, Hesami, Hamed, Alqutaibi, Ahmed Yaseen, Christensen, Hanne, Gholami, Ali, Hossain, Md. Belal, Bhaskar, Sonu, Chac\uf3n-Uscamaita, Pamela R Uscamaita, Choudhari, Sonali Gajanan, Bilalaga, Mariah Malak, Albashtawy, Mohammed, D'Amico, Emanuele, Baune, Bernhard T, Ali, Rafat, Anil, Abhishek, Akade, Seyed Esma'il, Fatehizadeh, Ali, Ariffin, Hany, Briko, Andrey, Afraz, Ali, Firouraghi, Neda, Hasani, Hamidreza, Bedi, Neeraj, Haddadi, Rasool, Abedi, Vida, Chimoriya, Ritesh, Gupta, Bhawna, Gan, Quan, Gholamrezanezhad, Ali, Bender, Rose G, Golechha, Mahaveer, Alimohamadi, Yousef, Begde, Ahmet, Dean, Frances E, Diaz, Daniel, Elshaer, Mohammed, Hayat, Khezar, Akbari, Morteza, Fathi, Saeid, Hassankhani, Hadi, Basu, Sanjay, Bhardwaj, Nikha, Arkew, Mesay, Dai, Zhaoli, Ghanbari, Reza, Hasaballah, Ahmed I., Cerin, Ester, Dabbagh Ohadi, Mohammad Amin, Elhabashy, Hala Rashad, Ancuceanu, Robert, Hartman, Nicholas Nathaniel, Alladi, Suvarna, Danawi, Hadi A, Elhadi, Muhammed, Ahmed, Ali, Al-amer, Rasmieh Mustafa, Costa, Vera Marisa, Begum, Tahmina, Ghaderi Yazdi, Bardiya, Bhangdia, Kayleigh, Ali, Mohammed Usman, Halwani, Rabih, Bashiri, Hamideh, Grivna, Michal, Bhatti, Gurjit Kaur, Galehdar, Nasrin, Edinur, Hisham Atan, Al Hasan, Syed Mahfuz, Ahmad, Sajjad, Brenner, Hermann, C\ue1rdenas, Rosario, Abdelmasseh, Michael, Couto, Rosa A S, Ghaffarpasand, Fariborz, Amugsi, Dickson A, Fathi, Mobina, Anderson, David B, Hargono, Arief, Belgaumi, Uzma Iqbal, Al-Shahi Salman, Rustam +499 morecore Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels
Advanced Science, EarlyView.A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma +17 morewiley +1 more sourceAlpha-Synuclein Lesions in the Peripheral Nervous System of the Larynx in Parkinson's Disease. [PDF]
DysphagiaMu L, Chen J, Nyirenda T, Li J, Hegland KW, Adler CH, Caviness JN, Shill HA, Serrano GE, Beach TG, Arizona Parkinson’s Disease Consortium. +10 moreeuropepmc +1 more sourceAn Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking
Advanced Science, EarlyView.This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang +8 morewiley +1 more sourceROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu +19 morewiley +1 more sourceSingle‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma
Advanced Science, EarlyView.Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu +13 morewiley +1 more sourceReal‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis
Advanced Science, EarlyView.A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang +15 morewiley +1 more source
