Results 41 to 50 of about 17,998,872 (270)
Drugs and the peripheral nervous system [PDF]
, 2017 Contents\ud \ud 7.1. Drugs and the sympathetic nervous system\ud \ud - 7.1.1 The sympathetic nervous system\ud \ud \ud - 7.1.2 Effects of the sympathetic nervous system\ud \ud \ud - 7.1.3 Sympathomimetics\ud \ud \ud - 7.1.4 Selective α1-adrenoceptor ...
Doggrell, Sheila
core
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
MFN2 KNOCKDOWN CAUSES NEUROMUSCULAR ALTERATIONS DURING ZEBRAFISH (DANIO RERIO) DEVELOPMENT: CHARACTERIZATION AND ANALYSIS OF A NEW MODEL FOR CHARCOT-MARIE-TOOTH TYPE 2A NEUROPATHY [PDF]
, 2011 Charcot-Marie-Tooth (CMT) diseases are the most common hereditary diseases of the peripheral nervous system. One of the most frequent, the dominant subtype CMT2A, is caused by mutations in the MFN2 gene coding for mitofusin 2, a dynamin-like GTPase ...
VETTORI, ANDREA +7 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Advanced Biomedical ResearchBackground: Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the major complications of chemotherapy regimens commonly used in the treatment of solid and hematologic cancers.
Ali Haji Gholami +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
The Korean Journal of Gastroenterology, 2016 Neurofibromas are benign, slow-growing nerve sheath tumors of the peripheral nervous system, arising from Schwann cells, and classically associated with neurofibromatosis type 1 (Nf1, von Recklinghausen’s disease).
Won Jik Lee +5 more
doaj +1 more source
Drugs and the autonomic nervous system [PDF]
, 2012 The nervous systems can initially be divided up into the central and peripheral nervous systems. The central nervous system is the brain and spinal cord and drugs that modify the central nervous system are considered as a subject in systematic ...
Doggrell, Sheila
core