Results 51 to 60 of about 17,998,872 (270)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Rare case of ancient schwannoma of the scalp: histopathologic and immunohistochemical insights

Archive of Clinical Medicine
Introduction. Schwannomas represent the most common benign peripheral nerve sheath tumors, predominantly affecting the head and neck area. Ancient schwannomas exhibit degenerative changes from prolonged growth but remain benign.
Geet Bhuyan, Sumanta Das, Reena Kouli
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Extracranial Head and Neck Schwannomas

Turkish Archives of Otorhinolaryngology
Objective: Schwannomas are benign tumors originating from the nerve sheath. Extracranial schwannomas account for 25-45% of schwannomas in the head and neck region.
Mehmet Birinci, Gökçe Aydın Balaban, Oğuzhan Okcu, Oğuz Gül, Tuğba Yemiş, Metin Çeliker, Özlem Çelebi Erdivanlı   +6 more
doaj   +1 more source

Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis

Frontiers in Immunology, 2020
Glioblastoma is one of the most common neoplasms in the central nervous system characterized by limited immune response and unlimited expansion capability.
You Zhai, Guanzhang Li, Renpeng Li, Yuanhao Chang, Yuemei Feng, Di Wang, Fan Wu, Wei Zhang, Wei Zhang, Wei Zhang   +9 more
doaj   +1 more source

Paclitaxel alters the microvascular network in the central and peripheral nervous system of rats with chemotherapy‐induced painful peripheral neuropathy [PDF]

Background and Aims: Chemotherapy-induced peripheral neurotoxicity (CIPN), with paraesthesia, numbness, dysesthesia and neuropathic pain ranks among the most common dose-limiting toxicity of several widely used anticancer drugs.
Elisa Ballarini, Virginia Rodriguez‐Menendez, Cristina Meregalli, Paola Alberti, Paola Coan, Eleonora Pozzi, Annalisa Canta, Laura Monza, Alberto Bravin, Giuliana Tromba, Valentina Alda Carozzi, Katrine Paiva, Giulia Saccomano, Antonio Giuliano Zippo, Alessia Chiorazzi, Guido Cavaletti, Elena Longo   +16 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

A Case of Cervical Intramedullary Dirofilaria immitis Associated with Nerve Sheath Tumor in a Dog [PDF]

Iranian Journal of Veterinary Surgery
Dirofilaria immitis, a globally widespread nematode known for its high mortality rate, primarily infests the cardiovascular system, notably the pulmonary artery and right ventricle.
Tohid Nasiribari, Zeynep Akçasız, Ebru Eravcı Yalın, Necati Öztürk, Damla Haktanır, Ahmet Gülçubuk   +5 more
doaj   +1 more source

Peripheral nervous system involvement in systemic amyloidosis [PDF]

, 2018
Peripheral nervous system involvement may be a main manifestation of systemic amyloidosis or occur in the later stages of the disease in the presence of multiple organ pathology.
L. V. Kozlovskaya-Lysenko, O. E. Zinovyeva, E. I. Safiulina, V. V. Rameev   +3 more
core   +1 more source