Results 71 to 80 of about 17,998,872 (270)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Neurological Findings in Myeloproliferative Neoplasms

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2013
Myeloproliferative neoplasms (MPN) arise from genetic deficiencies at the level of pluripotent stem cells. Each of these neoplasms is a clonal stem cell disorder with specific phenotypic, genetic and clinical properties.
Semra Paydas
doaj  

Limb cold therapy for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled study

World Journal of Surgical Oncology
Background Paclitaxel, a widely used chemotherapeutic drug for breast cancer, often causes peripheral neuropathy, which impacts patient quality of life and limits treatment dosages.
Danna Wu, Haiwei Bai, Yafei Zhang, Weina Wang   +3 more
doaj   +1 more source

The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog [PDF]

, 2006
We show that desert hedgehog ( dhh), a signaling molecule expressed by Schwann cells, is essential for the structural and functional integrity of the peripheral nerve.
Umehara, F, Meier, C, Turmaine, M, Jessen, KR, Sharghi-Namini, S, Sahni, V, Mirsky, R   +6 more
core  

Dorsal sural nerve conduction study in vitamin B12 deficiency with megaloblastic anemia

, 2006
International Meeting of the Peripheral-Nerve-Society -- FEB 06-JUN 08, 2006 -- Salt Lake City, UTPeripheral neuropathy is frequently observed in B-12 deficiency.
Tekguenduez, Emre, Pamuk, Guelsuem E., Turgut, Burhan, Akpinar, Seval, Balci, Kemal, Demir, Muzaffer, Turgut, Nilda   +6 more
core   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Schwannoma of the Recurrent Laryngeal Nerve, a Rare Neurogenic Tumor of the Middle Mediastinum: Diagnostic and Therapeutic Aspects

Инновационная медицина Кубани
Neurogenic tumors of the mediastinum represent a heterogeneous group of neoplasms arising from nervous tissue and account for up to 34% of all mediastinal tumors, predominantly localized in the posterior mediastinum.
E. B. Topolnitskiy, S. V. Usoltseva, N. A. Shefer, D. V. Kapitanova, I. G. Kotsar, Yu. V. Kardashova   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source