Results 191 to 200 of about 1,913,743 (283)

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Cone beam computed tomography-guided bronchoscopic sampling of peripheral pulmonary lesions: The first Indian experience. [PDF]

Lung India
Maturu VN, Garg VK, Prasad VP, Rachel R, Juvva KS, Kotla SS.   +5 more
europepmc   +1 more source

Mapping Tumor Recurrence and Metastasis With Pan‐Cancer Multi‐Omics

Med Research, EarlyView.
Tumor recurrence and metastasis arise from the interaction of shared evolutionary programs and context‐dependent modifiers. Clonal evolution, including genomic instability, subclonal selection, and treatment pressure, interacts with reversible cell‐state plasticity involving partial EMT, stemness, and dormancy, whereas immune escape, stromal remodeling,
Wenjun Meng, Ruicen Li, Xiaoli Mu, Xiaolong Tang, Yuxi Luo, Yingying Lei, Jinghong Xian, Guiyi Ji, Yihao Liu, Chenyu Huo, Sihan Li, Yalun Li, Jiadi Gan, Weimin Li   +13 more
wiley   +1 more source

Diagnostic utility of bronchoscopy for newly emerging peripheral pulmonary lesions after pulmonary resection. [PDF]

Transl Lung Cancer Res
Suzuki T, Matsumoto Y, Furuse H, Uchimura K, Imabayashi T, Tsuchida T.   +5 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Bronchoscope Size Selection for Improved Diagnostic Yield in Peripheral Pulmonary Lesions: A Retrospective Study. [PDF]

Cureus
Okafuji K, Kitamura A, Tomishima Y.
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Chinese expert consensus on shape-sensing robotic-assisted bronchoscopy (ssRAB) in the management of peripheral pulmonary lesions. [PDF]

Transl Lung Cancer Res
Xie F, Zhang C, Li C, Liu D, Zhang Q, Mu C, Hou G, Li M, Tang C, Xu F, Chen H, Chen Z, Gu Y, Guan Z, Ji C, Li H, Li W, Li X, Li Y, Lian H, Liao J, Luo Z, Ouyang H, Shen Y, Shi Y, Wan N, Wang T, Wang H, Wang H, Wang J, Wu J, Wu X, Xia Y, Xiao K, Xu W, Yang H, Yang J, Ye T, Ye X, Yu P, Zhang N, Zhang P, Zhao Q, Zheng X, Zou J, Chen E, Zhang H, Sun J, Professional Committee on Interventional Pulmonology of China Association for Promotion of Health Science and Technology, Expert Group on Technology of Shape-sensing Robotic-assisted Bronchoscopy.   +49 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Is the Thin Bronchoscope the Right Compromise Between Ultrathin and Conventional Bronchoscopy for Peripheral Pulmonary Lesions (PPLs)? A Retrospective Study. [PDF]

J Clin Med
Lanfranchi F, Castelli G, Mancino L, Foltran G, Michieletto L.   +4 more
europepmc   +1 more source