Results 141 to 150 of about 707,409 (240)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Peripheral Review Annual 2018

, 2019
"Peripheral Review is a platform for documenting and expanding the emerging and under-represented Canadian art scene, as well as enabling access for emerging writers by encouraging expanded and accessible critical dialogue." -- Publisher's ...
Iskandarsjah, Karina, Doherty, Shauna Jean, Andrews, Chris, Lavery, Lauren, Vuono, Christine, Marsh, Jenine, Adkins, Ella, Nyman, John, Haigh, Gillian   +8 more
core   +1 more source

Novel Insights into the Management of Painful Trigeminal Neuropathy: Targeting Peripheral and Central Pathomechanisms

Journal of Pain Research
You-Chia Chen,1,2 Hsinlin Thomas Cheng2 1Department of Neurology, Cathay General Hospital, Taipei, Taiwan, Republic of China; 2Department of Neurology, Mass General Brigham, Harvard Medical School, Boston, MA, USACorrespondence: Hsinlin Thomas Cheng ...
Chen YC, Cheng HT
doaj  

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications

Journal of Pain Research
Jiajun Xu,1,* Meng Wu,2,* Dao-peng Zhou,1 Hehong Gao,3 Weiwei Chen,3– 5 Jin-yan Teng3– 51School of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, People’s Republic of China; 2School of Acupuncture and ...
Xu J, Wu M, Zhou DP, Gao H, Chen W, Teng JY   +5 more
doaj  

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis

, 2014
Jane Yoo,1 Anne M Manicone,2 John K McGuire,3 Ying Wang,2 William C Parks2 1Center for Lung Biology, Department of Medicine, Division of Dermatology, 2Division of Pulmonary and Critical Care Medicine, 3Department of Pediatrics, Division Critical Care ...
McGuire JK, Parks WC, Yoo J, Manicone AM, Wang Y   +4 more
core  

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Color sensitivity of the peripheral retina.

, 1905
n ...
openaire   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source