Results 121 to 130 of about 707,409 (240)

Peripheral Mechanism of Hyperalgesia : Sensitization of Nociceptors

The peripheral mechanism of hyperalgesia is considered to be the result of nociceptor sensitization. As possible agents causing nociceptor sensitization, bradykinin, histamine, prostaglandin (PG)s, protons and nerve growth factor are evaluated with ...
MIZUMURA, KAZUE
core  

Modelo para estudo da nocicepção causada por extrato de espícula de Lonomia obliqua em ratos [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.
Bastos, Lúcia de Castro
core  

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Peripheral Sensitization

, 2020
Si-Qi Wei, Zhuo-Ying Tao, Yang Xue, Dong-Yuan Cao   +3 more
openaire   +2 more sources

Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The Rat

, 1999
Tissue injuries commonly cause an increase in pain sensitivity, so that normally painful stimuli become more painful (hyperalgesia), and those usually associated with nonnoxious sensations evoke pain (allodynia).
David Andrew, Joel D. Greenspan
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Mechanisms of pain occurrence in osteoarthritis: peripheral triggers, sensitization, and the path to persistence

Frontiers in Immunology
Osteoarthritis (OA) is a joint disease, and pain drives disability. Radiographic severity correlates poorly with pain intensity, indicating that OA pain cannot be explained by cartilage loss alone. This narrative review focuses on OA pain occurrence, the
Kai Huang, Haili Cai
doaj   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Modulazione movimento-correlata dei ritmi subtalamici in pazienti con malattia di parkinson

, 2005
G. Foffani, A. Priori
core   +2 more sources

Trigeminal neuralgia: peripheral and central mechanisms

Revista Dor
BACKGROUND AND OBJECTIVES: Trigeminal neuralgia is one of the most common neuropathic pains that compromise head and neck. It manifests as shock or burning pain normally evoked by non-noxious facial stimulations.
Grazielle Mara Ferreira Costa, Camila Megale de Almeida Leite   +1 more
doaj   +1 more source