Results 51 to 60 of about 707,409 (240)

Effects of Botulinum Toxin Type A on the Nociceptive and Lemniscal Somatosensory Systems in Chronic Migraine: An Electrophysiological Study

Toxins, 2023
(1) Background: OnabotulinumtoxinA (BoNT-A) is a commonly used prophylactic treatment for chronic migraine (CM). Although randomized placebo studies have shown its clinical efficacy, the mechanisms by which it exerts its therapeutic effect are still ...
Gabriele Sebastianelli, Francesco Casillo, Antonio Di Renzo, Chiara Abagnale, Ettore Cioffi, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Francesco Pierelli, Jean Schoenen, Gianluca Coppola   +10 more
doaj   +1 more source

Tetracyclic π‐Extended Multi‐Resonant TADF Emitters for Green PSF‐OLEDs With 37.7% EQE and BT.2020‐Compatible Top‐Emitting Devices

Advanced Functional Materials, EarlyView.
Ultra‐narrow green multi‐resonance thermally activated delayed fluorescence emitters have been developed by linear π‐extension strategy using tetracyclic naphtho[2,3‐b]benzofuran unit. The resulting phosphorescence‐sensitized OLEDs achieve a maximum external quantum efficiency of 37.7% in the bottom‐emitting architecture, while the complementary top ...
Eo Jin Jeon, Truong Thi Thuy, Nikita Abitkar, Paramasivam Palanisamy, Jiheon Kim, Myungsun Sim, Athithan Maheshwaran, Jang Hyuk Kwon   +7 more
wiley   +1 more source

Dendritic cells under allergic condition enhance the activation of pruritogen-responsive neurons via inducing itch receptors in a co-culture study

BMC Immunology
Background Itch sensitization has been reported in patients with chronic allergic skin diseases and observed in a mouse model of allergic contact dermatitis (ACD).
Tichakorn Singto, Viviane Filor, Jonathan Vidak, Robert Klopfleisch, Wolfgang Bäumer   +4 more
doaj   +1 more source

Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures [PDF]

, 2011
Background: Various effects on pain have been reported with respect to their statistical significance, but a standardized measure of effect size has been rarely added.
Karin Flühr, Doehring Alexandra, Flühr, Karin, Küsener, Nele, Jörn Lötsch, Doehring, Alexandra, Küsener Nele, Alexandra Doehring, Flühr Karin, Nele Küsener, Till J Neddermeyer, Lötsch Jörn, Neddermeyer, Till, Lötsch, Jörn, Neddermeyer Till J., Schneider, Gaby, Till J. Neddermeyer, Gaby Schneider, Schneider Gaby   +18 more
core   +2 more sources

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Neuropathic Pain Component in Musculoskeletal System Diseases: Review of the Literature and the Results of Own Researches. Part I

Bolʹ, Sustavy, Pozvonočnik, 2014
Treatment of chronic pain syndrome remains a challenge, especially in the elderly patients. Investigation of alternative mechanisms of pain occurrence will improve the effectiveness of treatment and quality of life in these patients. The article presents
V.V. Povoroznyuk, T.Ye. Shinkarenko, U.I. Pryimych   +2 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Atopic sensitization in the first year of life

, 2013
There is conflicting evidence on whether allergen-specific memory is primed prenatally, whether this priming affects persistent immunologic effects, and whether it is modulated by the first environmental exposures in infancy.; We sought to explore the ...
Ege, Markus J, Krauss-Etschmann, S., Pfefferle, P.I., Roduit, Caroline; https://orcid.org/, Braun-Fahrländer, C., Riedler, J., Hirvonen, Maija-Riitta, Weber, J., Ege, Markus J., Pfefferle, Petra I., Dalphin, J.-C., von Mutius, E., Hirvonen, M.R., von Mutius, Erika, Roduit, C., Lauener, R., Kaulek, Vincent, Ege, M.J., Depner, Martin, Roponen, Marjut, Braun-Fahrlaender, Charlotte, Pfefferle, Petra I, Pekkanen, J., Roponen, M., Depner, M., Renseigné, Non, Lauener, Roger, Pasture Study Group,, Dalphin, Jean-Charles, Genuneit, J., Pekkanen, Juha, Krauss-Etschmann, Susanne, Kaulek, V., Riedler, Josef, Roduit, Caroline, Genuneit, Jon, Braun-Fahrländer, Charlotte, Weber, Juliane   +37 more
core   +1 more source

Structure-Property-Performance Relationships of Dielectric Nanostructures for Mie Resonance-Enhanced Dye-Sensitization

, 2021
Dye-sensitized photocatalytic (DSP) approach is considered as one of the promising approaches for developing visible light- and near-infrared light-responsive photocatalysts.
Sundaram Bhardwaj Ramakrishnan (9017405), Farshid Mohammadparast (6576470), Susheng Tan (1596295), Swetha M. Arumugam (14407797), Ravi Teja Addanki Tirumala (14356914), Marimuthu Andiappan (1455565)   +5 more
core   +1 more source