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Pathogenesis of Peripheral T Cell Lymphoma [PDF]

Annual Review of Pathology: Mechanisms of Disease, 2018
Peripheral T cell lymphomas (PTCLs) are highly heterogeneous tumors, displaying distinct clinical and biological features. The pathogenesis and normal counterpart of such entities have been elusive for decades. Recent studies have, however, disclosed key mechanisms of peripheral T cell transformation, including (a) the deregulation of signaling ...
Pizzi, Marco, Margolskee, Elizabeth, Inghirami, Giorgio   +2 more
openaire   +4 more sources

Peripheral T Cell Lymphoma: Not Otherwise Specified

Indian Journal of Dermatology, 2015
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of hematological tumors originating from mature T cells, which constitutes less than 15% of all non-Hodgkins lymphomas in adults. Primary cutaneous PTCL-not otherwise specified (NOS) represent a subgroup of PTCLs with no consistent immunophenotypic, genetic or clinical features.
Anusha H Pai, Anne George, Deepa Adiga, Banavasi S Girisha   +3 more
openaire   +4 more sources

Genetic Landscape of Peripheral T-Cell Lymphoma

Life, 2022
Peripheral T-Cell lymphoma (PTCL) comprises a heterogenous group of uncommon lymphomas derived from mature, post-thymic or “peripheral” T- and natural killer cells. The World Health Organization (WHO) emphasizes a multiparameter approach in the diagnosis
Vivian Hathuc, Friederike Kreisel
doaj   +1 more source

Peripheral T-cell lymphoma [PDF]

Cancer, 1989
Peripheral T-cell lymphoma is the most common type of T-cell lymphoma seen in adults in the United States. Clinical data were reviewed from 134 cases of peripheral T-cell lymphoma diagnosed in three centers. The median age of the patients was 57 years (range, 4-97 years), 59% were male, and 36 patients (27%) had a history of a preceding disorder of the
James O. Armitage, John P. Greer, Alexandra M. Levine, Dennis D. Weisenburger, Silvia C. Formenti, Martin Bast, Sue Conley, Jene Pierson, James Under, John B. Cousar, Bharat N. Nathwani   +10 more
openaire   +2 more sources

Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas

Experimental Hematology & Oncology, 2021
Background The 2016 World Health Organization (WHO) classification introduced nodal lymphomas of T follicular helper (Tfh) cell origin, such as angioimmunoblastic T-cell lymphoma (AITL), follicular peripheral T-cell lymphoma (F-PTCL), and nodal ...
Sang Eun Yoon, Junhun Cho, Yeon Jeong Kim, Young Hyeh Ko, Woong-Yang Park, Seok Jin Kim, Won Seog Kim   +6 more
doaj   +1 more source

Extranodal NK/T-cell lymphoma, nasal type presenting as primary intestinal lymphoma vs intestinal T-cell lymphoma: A borderline diagnostic category in the revised WHO classification

Human Pathology: Case Reports, 2021
Extranodal NK/T-cell lymphoma, nasal type, is an unusual Epstein-Barr Virus (EBV)-related lymphoma that carries a poor prognosis. Most cases affect upper aerodigestive tract, and secondarily may extend to skin, lungs, testis, and other sites.
Brady E. Beltrán, Mario L. Marques-Piubelli, M. Pilar Quiñones, Esther Cotrina, Eugenio A. Palomino, Johnny Morales, Wilder Ramos, Eduardo M. Sotomayor, Julio C. Chavez, Jorge J. Castillo, Roberto N. Miranda   +10 more
doaj   +1 more source

Peripheral T-cell lymphomas

Annals of Oncology, 1991
The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation. The cells of the first differentiation wave are the precursor T cells, and those of the second differentiation wave are peripheral T cells.
H, Stein, D, Dienemann, F, Dallenbach, M, Kruschwitz   +3 more
openaire   +4 more sources

Morphological characterization of canine retrobulbar lymphoma [PDF]

Open Veterinary Journal, 2018
This report characterized seven cases of canine retrobulbar lymphoma that have been diagnosed during 2008 to 2014 by immunophenotyping of CD3 and Pax5. Classification of lymphoma were performed according to the revised WHO guidelines.
Natthanet Sritrakoon, Kannika Siripattarapravat, Phudit Maneesaay, Chidozie J. Amuzie, Aree Thayananuphat   +4 more
doaj   +1 more source

Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes

Hemato, 2022
Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi, Kristin H. Karner, Madhu P. Menon   +2 more
doaj   +1 more source

Transcript-indexed ATAC-seq for precision immune profiling. [PDF]

, 2018
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D, Chang, Howard Y, Corces, M Ryan, Davis, Mark M, Gennert, David G, Granja, Jeffrey M, Greenleaf, William J, Khavari, Paul A, Khodadoust, Michael S, Kim, Youn H, Lareau, Caleb A, Li, Rui, Mumbach, Maxwell R, Parker, Kevin R, Qi, Yanyan, Rubin, Adam J, Saligrama, Naresha, Satpathy, Ansuman T, Schep, Alicia N, Serratelli, William S, Wei, Yuning, Wu, Beijing   +21 more
core   +1 more source