Results 111 to 120 of about 80,953 (281)
Territoire en MouvementThe tension between planning and project-based urban planning is a classic debate in spatial planning. This tension is reinforced by the major transformations of Moroccan cities, particularly in their peripheries.
Maryame Amarouche
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Irregular Urbanization as a Catalyst for Radical Social Mobilization: The Case of the Housing Movements of São Paulo [PDF]
This study focuses on the city of São Paulo, Brazil and examines the ways in which irregular and illegal growth have influenced the collective action of social movements of the urban poor.
Lucy Earle
core
Permanent Peoples’ Tribunal – Session on: Workers and Consumers Rights in the Garment Industry [PDF]
, 1998 A report from the International Forum on Clean Clothes, outlining the status of human and labor rights in the garment industry and presenting proposals for ...
Clean Clothes Campaign
core +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
New urban frontiers: contemporary tendencies in Brazil’s urbanization [PDF]
Brazil ...
Roberto Luís de Melo Monte-Mór
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Standard GRB, Dirty Fireballs, and the Excluded Middle
, 2011 It is shown that the contribution of faint gamma-ray bursts (GRB) to the total allsky GRB energy flux is small. The allsky flux of GRB appears to be $5.3 \times 10^{-3}$ erg/$\rm cm^2 y$, with little additional component hidden within weak or otherwise ...
Band +7 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source