Results 71 to 80 of about 409,478 (258)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Socio-economic changes in the borderlands of the Visegrad Group (V4) countries
Moravian Geographical Reports, 2015 Under the influence of globalization and state integration processes, the importance of a border as a barrier is gradually decreasing. Borderlands are still perceived as specific phenomena, however, not only in terms of historical development but ...
Máliková Lucia +3 more
doaj +1 more source
The International Journal of the History of Sport, 2017 Kurkowska-Budzan, Marta +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
L'Espace Politique, 2007 This paper aims to study the ambiguous relationship between the European Union and the countries of the Western Balkans which are waiting for their accession.
Emmanuelle Chaveneau, Amaël Cattaruzza
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
From the Periphery to the Deep End: A Critique of Joshua Maponga’s Religio-Cultural Pedagogy [PDF]
E-Journal of Religious and Theological StudiesA plethora of discourses have emerged on the religio-cultural pedagogy of Joshua Maponga, a Zimbabwean clergy. Maponga’s religious and cultural pedagogy has been oscillating from the periphery to the deep end.
Peter Masvotore, Martin Mujinga
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
An entrepreneurial countryside?
Cidades, Comunidades e Território, 2021 Architecture and urban design are central selling points in globalized models of urban development, advocated by city strategies to boost competitiveness.
Heini-Emilia Saari
doaj