Results 71 to 80 of about 416,455 (267)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
L'Espace Politique, 2007 This paper aims to study the ambiguous relationship between the European Union and the countries of the Western Balkans which are waiting for their accession.
Emmanuelle Chaveneau, Amaël Cattaruzza
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
From the Periphery to the Deep End: A Critique of Joshua Maponga’s Religio-Cultural Pedagogy [PDF]
E-Journal of Religious and Theological StudiesA plethora of discourses have emerged on the religio-cultural pedagogy of Joshua Maponga, a Zimbabwean clergy. Maponga’s religious and cultural pedagogy has been oscillating from the periphery to the deep end.
Peter Masvotore, Martin Mujinga
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
An entrepreneurial countryside?
Cidades, Comunidades e Território, 2021 Architecture and urban design are central selling points in globalized models of urban development, advocated by city strategies to boost competitiveness.
Heini-Emilia Saari
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Analyzing urban sprawl and urbanisation dynamics: A case study of Bejaia, Oued-Ghir, and Tala-Hamza [PDF]
Glasnik Srpskog Geografskog DruštvaUnderstanding urban sprawl is crucial as it provides a dynamic perspective on urban areas, revealing the driving forces and explanatory factors behind their expansion.
Tebbane Bouktit Kaouther +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
MODERN GEODEMOGRAPHIC SITUATION IN PERIPHERAL RURAL AREAS IN THE SOUTH OF EUROPEAN RUSSIA
Наука. Инновации. Технологии, 2022 The demographic situation in Russia, despite the measures taken, largely retains negative. Low fertility combined with high mortality led to the depopulation effect resulting in natural population decline in many regions of the country, which can not ...
Natalia Aleksandrovna Shchitova +1 more
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