Results 31 to 40 of about 26,622 (265)

Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis

Journal for ImmunoTherapy of Cancer, 2020
Background Peritoneal carcinomatosis is a hallmark of advanced peritoneal tumor progression, particularly for tubal/ovarian high-grade serous carcinomas (HGSCs).
Chien-Fu Hung, Ssu-Hsueh Tseng, Sung-Taek Park, Brandon Lam, Ya-Chea Tsai, Max A Cheng, Emily Farmer, Deyin Xing   +7 more
doaj   +1 more source

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Exploring the HYDRAtion method for loading siRNA on liposomes : the interplay between stability and biological activity in human undiluted ascites fluid [PDF]

, 2016
Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)trimethylammonium
Braeckmans, Kevin, Ceelen, Wim, Dakwar, George, De Smedt, Stefaan, Remaut, Katrien   +4 more
core   +2 more sources

Peritoneal Tuberculosis Mimicking Peritoneal Carcinomatosis

Medical Journal of Zambia, 2018
Tuberculosis is a serious infection that can appear in many forms and presentations. Here, we highlight a case of a 13 year old patient with a three-month history of nonspecific abdominal pain whose symptoms persisted after treating Typhoid and H. pylori infections.
Martynov, A, Saleeb, M.S., Saleeb, Y.M., Kerolos, M.M., Zaki, M.M.   +4 more
openaire   +2 more sources

Diagnostic Value of Carcinoembryonic Antigen in Ascites for Colorectal Cancer with Peritoneal Carcinomatosis

The Korean Journal of Gastroenterology, 2018
Background/Aims: Diagnostic tests for carcinoembryonic antigen (CEA) in ascites have been performed in various malignant cases, but there is only few data on the applicability of CEA for colorectal cancer (CRC) patients with peritoneal carcinomatosis. We
Sung Eun Song, Paul Choi, Jae Hyun Kim, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park   +7 more
doaj   +1 more source

Intraperitoneal chemotherapy for peritoneal metastases : an expert opinion

, 2020
Introduction: The rationale for intraperitoneal (IP) drug delivery for patients with peritoneal metastases (PM) is based on the pharmacokinetic advantage resulting from the peritoneal-plasma barrier, and on the potential to adequately treat small, poorly
Braet, Helena, Ceelen, Wim, Remaut, Katrien, Van Ramshorst, Gabrielle, Willaert, Wouter   +4 more
core   +1 more source

Disregarded effect of biological fluids in siRNA delivery : human ascites fluid severely restricts cellular uptake of nanoparticles [PDF]

, 2015
Small interfering RNA (siRNA) offers a great potential for the treatment of various diseases and disorders. Nevertheless, inefficient in vivo siRNA delivery hampers its translation into the clinic.
Braeckmans, Kevin, Ceelen, Wim, Dakwar, George, De Smedt, Stefaan, Demeester, Jo, Remaut, Katrien   +5 more
core   +2 more sources

Clinical and Radiological Parameters to Discriminate Tuberculous Peritonitis and Peritoneal Carcinomatosis

Diagnostics, 2023
It is challenging to differentiate between tuberculous peritonitis and peritoneal carcinomatosis due to their insidious nature and intersecting symptoms. Computed tomography (CT) is the modality of choice in evaluating diffuse peritoneal disease.
Daya K. Jha, Pankaj Gupta, Pardhu B. Neelam, Rajender Kumar, Venkata S. Krishnaraju, Manish Rohilla, Ajay S. Prasad, Usha Dutta, Vishal Sharma   +8 more
doaj   +1 more source

Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer

BMC Cancer, 2010
Background Gastric cancer peritoneal carcinomatosis is a common clinical problem, but there are no suitable large animal models to study this problem. This study was to establish a stable rabbit peritoneal carcinomatosis model of gastric cancer using VX2
Yonemura Yutaka, Hassan Alaa, Tang Li, Yang Xiao-Jun, Mei Lie-Jun, Li Yan   +5 more
doaj   +1 more source

Cytoreduction and HIPEC in the treatment of "unconventional" secondary peritoneal carcinomatosis [PDF]

, 2015
BACKGROUND: Peritoneal metastasis (PM) is considered a terminal and incurable disease. In the last 30 years, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) radically changed the therapeutic approach for these patients ...
Accarpio, Fabio, Biacchi, Daniele, Cardi, Maurizio, DI GIORGIO, Angelo, Mingarelli, Valentina, Musio, Daniela, Sammartino, Paolo, Sibio, Simone, Sollazzo, BIANCA MARIA   +8 more
core   +2 more sources