Results 81 to 90 of about 2,354,831 (307)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Continuous ambulatory peritoneal dialysis. Experience in Villa Clara

Acta Médica del Centro, 2013
One of the health problems with a major contribution to mortality and morbidity in developed and developing countries are noncommunicable diseases, among which chronic kidney disease is well identified. It may be secondary or the final common pathway
Lexis C. Ramírez Felipe, Erich Galdo Gómez, Leidy E. Lastra Venegas   +2 more
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Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology

Bioengineering & Translational Medicine
The peritoneum, the body's largest serous membrane, plays critical roles in abdominal homeostasis and immune defense. When disrupted by surgery or disease, it can lead to devastating complications including peritoneal adhesions—affecting up to 93% of ...
Katharina Peisert, Franziska Keßler, Sara Y. Brucker, Jan Pauluschke‐Fröhlich, Peter Jakubowski, Felix Neis, Bernhard Krämer, Jürgen Andress, Adrian Weghofer, Hui‐Yu Liu, Peter Loskill, Martin Weiss   +11 more
doaj   +1 more source

Research progress in tamoxifen in treatment of encapsulating peritoneal sclerosis [PDF]

Xin yixue
Encapsulating peritoneal sclerosis（EPS）is a rare and serious complication in patients with long-term peritoneal dialysis and a history of recurrent and severe peritoneal dialysis-associated peritonitis（PDAP）.
Kang Daxian, Sun Liping, Zhang Xinzhou
doaj   +1 more source

Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer.

PLoS ONE, 2020
BACKGROUND:Peritoneal recurrence is one of the most frequent recurrent diseases in gastric cancer. Although the exposure of cancer cells to the serosal surface is considered a common risk factor for peritoneal recurrence, there are some cases of ...
Shingo Togano, Masakazu Yashiro, Yuichiro Miki, Yurie Yamamoto, Tomohiro Sera, Yukako Kushitani, Atsushi Sugimoto, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Tomohisa Okuno, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Sayaka Tanaka, Masaichi Ohira   +17 more
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Time for a “Plan B” in Peritoneal Metastatic Disease [PDF]

Cancer Research, 2019
Abstract Peritoneal involvement in cancer is the harbinger of a particularly unfavorable prognosis. The peritoneal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage populations and innate-like B-1 B cells, which provide immune privilege to malignant cell foci.
openaire   +3 more sources

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Non-Hodgkin Lymphoma Presented with Peritoneal Seeding: A Case Report

Case Reports in Clinical Practice, 2017
Lymphoma is the most common malignancy originating from hematopoietic systems. Diverse biological and clinical manifestations of non-Hodgkin lymphoma have been recognized. As an unusual type of non-Hodgkin lymphoma is Burkitt lymphoma. The variability of
Mohammadreza Salehi, Fatemeh Talebi, Alireza Ghanadan, Niloofar Ayoobi Yazdi   +3 more
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