Results 61 to 70 of about 153,755 (264)

Extracellular Vesicles of Patients on Peritoneal Dialysis Inhibit the TGF-β- and PDGF-B-Mediated Fibrotic Processes

Cells
Among patients on peritoneal dialysis (PD), 50–80% will develop peritoneal fibrosis, and 0.5–4.4% will develop life-threatening encapsulating peritoneal sclerosis (EPS).
Beáta Szebeni, Apor Veres-Székely, Domonkos Pap, Péter Bokrossy, Zoltán Varga, Anikó Gaál, Judith Mihály, Éva Pállinger, István M. Takács, Csenge Pajtók, Mária Bernáth, György S. Reusz, Attila J. Szabó, Ádám Vannay   +13 more
doaj   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Analysis of outcomes and risk factors in peritoneal dialysis patients in a single center

Linchuang shenzangbing zazhi, 2020
Objective To analyze the clinical data of peritoneal dialysis(PD)patients in the Second Hospital of Shanxi Medical University,and to explore the outcomes of patients with PD and the risk factors.Methods The clinical data of patients with maintenance ...
YUAN Ming, QIAO Yu-feng, YAN Yan, LI Xiao-xia, XUE Fu-ping, LIU Hong-yan, WANG Li-hua   +6 more
doaj  

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Microscopic distance from tumor invasion front to serosa might be a useful predictive factor for peritoneal recurrence after curative resection of T3-gastric cancer.

PLoS ONE, 2020
BACKGROUND:Peritoneal recurrence is one of the most frequent recurrent diseases in gastric cancer. Although the exposure of cancer cells to the serosal surface is considered a common risk factor for peritoneal recurrence, there are some cases of ...
Shingo Togano, Masakazu Yashiro, Yuichiro Miki, Yurie Yamamoto, Tomohiro Sera, Yukako Kushitani, Atsushi Sugimoto, Shuhei Kushiyama, Sadaaki Nishimura, Kenji Kuroda, Tomohisa Okuno, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Sayaka Tanaka, Masaichi Ohira   +17 more
doaj   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Continuous ambulatory peritoneal dialysis. Experience in Villa Clara

Acta Médica del Centro, 2013
One of the health problems with a major contribution to mortality and morbidity in developed and developing countries are noncommunicable diseases, among which chronic kidney disease is well identified. It may be secondary or the final common pathway
Lexis C. Ramírez Felipe, Erich Galdo Gómez, Leidy E. Lastra Venegas   +2 more
doaj  

Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology

Bioengineering & Translational Medicine
The peritoneum, the body's largest serous membrane, plays critical roles in abdominal homeostasis and immune defense. When disrupted by surgery or disease, it can lead to devastating complications including peritoneal adhesions—affecting up to 93% of ...
Katharina Peisert, Franziska Keßler, Sara Y. Brucker, Jan Pauluschke‐Fröhlich, Peter Jakubowski, Felix Neis, Bernhard Krämer, Jürgen Andress, Adrian Weghofer, Hui‐Yu Liu, Peter Loskill, Martin Weiss   +11 more
doaj   +1 more source

Research progress in tamoxifen in treatment of encapsulating peritoneal sclerosis [PDF]

Xin yixue
Encapsulating peritoneal sclerosis（EPS）is a rare and serious complication in patients with long-term peritoneal dialysis and a history of recurrent and severe peritoneal dialysis-associated peritonitis（PDAP）.
Kang Daxian, Sun Liping, Zhang Xinzhou
doaj   +1 more source