Results 71 to 80 of about 2,354,831 (307)

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Extracellular Vesicles of Patients on Peritoneal Dialysis Inhibit the TGF-β- and PDGF-B-Mediated Fibrotic Processes

Cells
Among patients on peritoneal dialysis (PD), 50–80% will develop peritoneal fibrosis, and 0.5–4.4% will develop life-threatening encapsulating peritoneal sclerosis (EPS).
Beáta Szebeni, Apor Veres-Székely, Domonkos Pap, Péter Bokrossy, Zoltán Varga, Anikó Gaál, Judith Mihály, Éva Pállinger, István M. Takács, Csenge Pajtók, Mária Bernáth, György S. Reusz, Attila J. Szabó, Ádám Vannay   +13 more
doaj   +1 more source

Systematic review of the effectiveness of preventing and treating Staphylococcus aureus carriage in reducing peritoneal catheter-related infections [PDF]

, 2007
Objectives: To determine the clinical effectiveness and cost-effectiveness of (1) alternative strategies for the prevention of Staphylococcus aureus carriage in patients on peritoneal dialysis (PD) and (2) alternative strategies for the eradication of S.
Fraser, Cynthia Mary, L Vale, Fraser, C., K Rabindranath, I Gould, McCormack, Kirsty, Kilonzo, Mary Mueni, Rabindranath, K., C Fraser, Valery, L., Gould, Ian M, Kilonzo, M., S Thomas, Fluck, N., Waugh, N., Rothnie, H., H Rothnie, N Waugh, Gould, I., K McCormack, N Fluck, Thomas, S., M Kilonzo, McCormack, K., L McIntyre, McIntyre, L., Waugh, Norman Robert, Vale, Luke David, Thomas, Sumesh   +28 more
core   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

The relationship between peritoneal leukocyte count, fluid cultures, and clinical results in peritonitis among peritoneal dialysis patients: is there a geographic or ethnic difference?

, 2021
We investigated peritoneal leukocyte count (PLC) and culture results for correlations with inflammation, nutrition, microbiologic parameters, and the effects of peritonitis on peritoneal equilibration tests (PETs) and clinical outcomes in peritoneal ...
Ozturk, Savaş, KAZANCIOĞLU, Rümeyza, Bozfakioglu, Semra, Altas, Kazim, Yazici, Halil, Sar, Fuat, Uzun, Sami   +6 more
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Analysis of outcomes and risk factors in peritoneal dialysis patients in a single center

Linchuang shenzangbing zazhi, 2020
Objective To analyze the clinical data of peritoneal dialysis(PD)patients in the Second Hospital of Shanxi Medical University,and to explore the outcomes of patients with PD and the risk factors.Methods The clinical data of patients with maintenance ...
YUAN Ming, QIAO Yu-feng, YAN Yan, LI Xiao-xia, XUE Fu-ping, LIU Hong-yan, WANG Li-hua   +6 more
doaj  

What does peritoneal thickness in peritoneal dialysis patients tell us?

, 2007
Loss of peritoneal function is a major factor leading to failure of treatment in peritoneal dialysis (PD). Although the precise biologic mechanisms responsible for these changes have not been defined, the general assumption is that alterations in ...
Duman S., Ertilav M., Ozbek S.S., Sipahi S., Ok E., Bozkurt D., Asci G., Kirçelli F., Gunay E.S., Ozkahya M.   +9 more
core