Results 51 to 60 of about 71,423 (312)

Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways [PDF]

, 2017
Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD,
Alejandro Pacheco, Alejandro Vallejos, Cesar Echeverria, Erico Segovia, Felipe Simon, Felipe Simon, Maria E. Sanhueza, Miriam Alvo, Pablo Tapia, Ricardo Armisen, Ricardo Armisen, Rubén Torres, Rubén Torres, Sebastian Gatica   +13 more
core   +2 more sources

Therapeutic Targeting of GSK3β-Regulated Nrf2 and NFκB Signaling Pathways by Salvianolic Acid A Ameliorates Peritoneal Fibrosis

Frontiers in Medicine, 2022
Peritoneal fibrosis is a devastating complication in patients undergoing peritoneal dialysis, with no definite therapy yet available. Salvia miltiorrhiza and its major active component Salvianolic acid A (Sal A) have demonstrated a beneficial effect in ...
Fan Zhou, Fan Zhou, Lan Yao, Xiaoqing Lu, Yubao Li, Xingmin Han, Xingmin Han, Pei Wang   +7 more
doaj   +1 more source

BEV-IP : perioperative chemotherapy with bevacizumab in patients undergoing cytoreduction and intraperitoneal chemoperfusion for colorectal carcinomatosis [PDF]

, 2015
Background: Selected patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) benefit from cytoreductive surgery (CRS) combined with intraperitoneal chemoperfusion (IPC).
Ceelen, Wim, Liberale, Gabriel, Van Der Speeten, Kurt, Willaert, Wouter   +3 more
core   +2 more sources

Peritoneal fibrosis-future prevention strategies

Hong Kong Journal of Nephrology, 2003
AbstractPeritoneal fibrosis is one of the most serious complications of peritoneal dialysis, and is characterized by the activation of peritoneal resident cells (mesothelial cells, endothelial cells, fibroblasts and macrophages), induction of pro-fibrotic peptides, accumulation and deposition of excess matrix proteins within the submesothelium, and ...
Chan, TM, Yung, S
openaire   +2 more sources

Saha Suppresses Peritoneal Fibrosis in Mice [PDF]

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2015
Objective Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences. Among epigenetic modifications, histone acetylation leads to the transcriptional activation of genes.
Kumiko, Io, Tomoya, Nishino, Yoko, Obata, Mineaki, Kitamura, Takehiko, Koji, Shigeru, Kohno   +5 more
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Smad7 gene transfer inhibits peritoneal fibrosis [PDF]

Kidney International, 2007
Fibrosis mediated by transforming growth factor-beta (TGF-beta) is a common cause of peritoneal dialysis (PD) failure. In a model of peritoneal fibrosis, we tested the effect of Smad7, an inhibitor of TGF-beta signaling, using an ultrasound-microbubble-mediated delivery system.
Nie, J., Dou, X., Hao, W., Wang, X., Peng, W., Jia, Z., Chen, W., Li, X., Luo, N., Lan, H.Y., Yu, X.Q.   +10 more
openaire   +2 more sources

Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats. [PDF]

PLoS ONE, 2012
The benefits of long-term peritoneal dialysis (PD) in patients with end-stage renal failure are short-lived due to structural and functional changes in the peritoneal membrane.
Juan Pérez-Martínez, Francisco C Pérez-Martínez, Blanca Carrión, Jesús Masiá, Agustín Ortega, Esther Simarro, Syong H Nam-Cha, Valentín Ceña   +7 more
doaj   +1 more source

Neutral solution low in glucose degradation products is associated with less peritoneal fibrosis and vascular sclerosis in patients receiving peritoneal dialysis. [PDF]

, 2012
BACKGROUND: The effects of novel biocompatible peritoneal dialysis (PD) solutions on human peritoneal membrane pathology have yet to be determined. Quantitative evaluation of human peritoneal biopsy specimens may reveal the effects of the new solutions ...
HONDA Kazuho, KAWANISHI Kunio, NITTA Kosaku, ODA Hideaki, TSUKADA Misao   +4 more
core   +2 more sources

Targeting lysyl oxidase reduces peritoneal fibrosis [PDF]

PLOS ONE, 2017
Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature.
Christopher R. Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E. Kadler, Yinhui Lu, J. Ian Mason, Hilary O. D. Critchley, Stephen G. Hillier   +12 more
openaire   +5 more sources