Results 61 to 70 of about 408,139 (189)

Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway

Renal Failure
Increasing evidence suggests that peritoneal fibrosis induced by peritoneal dialysis (PD) is linked to oxidative stress. However, there are currently no effective interventions for peritoneal fibrosis.
Ying Lu, Luyan Gao, Wenwen Zhang, Ying Zeng, Ji Hu, Kai Song   +5 more
doaj   +1 more source

Peritonitis-induced peritoneal injury models for research in peritoneal dialysis review of infectious and non-infectious models

Renal Replacement Therapy, 2017
Peritonitis is an important complication of peritoneal dialysis. Several animal peritonitis models have been described, including bacterial and fungal models that are useful for studying inflammation in peritonitis. However, these models have limitations
Yasuhiko Ito, Hiroshi Kinashi, Takayuki Katsuno, Yasuhiro Suzuki, Masashi Mizuno   +4 more
doaj   +1 more source

Tissue Models of Peritoneal Fibrosis

, 2005
ObjectiveTo evaluate the utility of peritoneal pathologic samples, unrelated to peritoneal dialysis (PD) treatment, for the study of peritoneal fibrosis and inflammation.MethodsComparative morphologic and immunohistochemical study of peritoneal ...
J.A. Jiménez-Heffernan, C. Perna, M.A. Bajo, G. Del Peso, M. LÓpez-Cabrera, R. Selgas, A. Cirugeda, M.L. Pérez-Lozano   +7 more
core   +1 more source

Expanding the Phenotypic Spectrum of TXNDC15‐Related Ciliopathies to Include Joubert Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic loss‐of‐function variants in TXNDC15 are a known cause of the perinatally lethal ciliopathy Meckel syndrome (MKS). TXNDC15 encodes an endoplasmic reticulum (ER)‐resident thioredoxin‐domain protein required for ciliary transition zone integrity.
Zachary T. Sentell, Robert Geraghty, Juliana E. Arcila‐Galvis, Praveen Dhondurao‐Sudhindar, Sergio Foullerat Cañada, Fulvio D'Abrusco, Bosanka Jocic‐Jakubi, Miguel Barroso‐Gil, Valentina Serpieri, Thomas M. Kitzler, Kate E. Chandler, Eleanor G. Seaby, Gabrielle Wheway, Jennifer C. Dempsey, Dan Doherty, Enza M. Valente, John A. Sayer   +16 more
wiley   +1 more source

Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis

Communications Biology, 2021
Li et al. show that dipeptidyl peptidase 4 (DPP4) promotes peritoneal fibrosis whereas the inhibition of DPP4 protects the patients from failure of peritoneal dialysis.
Yi-Chen Li, Pei-Hsun Sung, Yao-Hsu Yang, John Y. Chiang, Hon-Kan Yip, Chih‐Chao Yang   +5 more
doaj   +1 more source

Fn14 protein expression in peritoneal tissue correlates with peritoneal injury, fibrosis and inflammation in humans.

, 2014
Scatter plot showing the significant positive correlation between Fn14 expression in peritoneal tissue from non-infected patients (n = 9) and histological peritoneal injury, peritoneal fibrosis and peritoneal inflammation scores.
Luiz Stark Aroeira (260964), Gloria del Peso (405935), Maria Dolores Sanchez-Niño (303063), Rafael Selgas (260970), Teresa Bellon (531095), Manuel Lopez-Cabrera (181137), Beatriz Santamaria (5658298), Jesus Egido (2652502), Jose Jimenez-Heffernan (531096), Alberto Ortiz (108398), Luis Miguel Blanco-Colio (2333821), Marta Ruiz-Ortega (108389), Ana Belen Sanz (303062)   +12 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis. [PDF]

PLoS ONE, 2013
Mesothelial-to-mesenchymal transition (MMT) is an auto-regulated physiological process of tissue repair that in uncontrolled conditions such as peritoneal dialysis (PD) can lead to peritoneal fibrosis.
Jesús Loureiro, Pilar Sandoval, Gloria del Peso, Guadalupe Gónzalez-Mateo, Vanessa Fernández-Millara, Beatríz Santamaria, Maria Auxiliadora Bajo, José Antonio Sánchez-Tomero, Gonzalo Guerra-Azcona, Rafael Selgas, Manuel López-Cabrera, Abelardo I Aguilera   +11 more
doaj   +1 more source