Results 51 to 60 of about 408,139 (189)

STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose

Journal of Translational Medicine, 2021
Background Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might mediate the process of renal fibrosis ...
Xiaoxiao Yang, Manchen Bao, Yi Fang, Xiaofang Yu, Jun Ji, Xiaoqiang Ding   +5 more
doaj   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis [PDF]

, 2016
Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water.
AMICONE, Laura, BATTISTELLI, CECILIA, CICCHINI, Carla, Laura Amicone, Alessandra Marchetti, Marco Tripodi, Raffaele Strippoli, Carla Cicchini, TRIPODI, Marco, Moreno Vicente, Roberto, Roberto Moreno-Vicente, Miguel Angel del Pozo, Valeria Noce, NOCE, VALERIA, Del Pozo, Miguel Angel, Cecilia Battistelli, Moreno-Vicente, Roberto, STRIPPOLI, RAFFAELE, MARCHETTI, ALESSANDRA   +18 more
core   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

Advanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi, Sukyoung Han, Jinho Kim, Ji Hye Han, Eunsu Kim, Yeonjeong Heo, Minju Lee, Jooyoung Lee, Heerim You, Soyoun Lee, Su‐Hee Han, Ilrok Yoon, Sung Anjeon, Hyerim Kang, Seungyeon Ryu, Hyun‐Ji Park, Eunha Kim, Chul Hwan Bang, Ji Hyun Lee, Josephine M. Egan, Jung‐Woong Kim, Eun Kyung Lee, Wook Kim   +22 more
wiley   +1 more source

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Redefining the Role of Splenectomy in Scirrhous Gastric Cancer: Toward a Selective Multimodal Strategy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Scirrhous gastric cancer, characterized by diffuse infiltration and a high propensity for peritoneal dissemination, remains one of the most aggressive subtypes of gastric cancer. Despite a relatively high incidence of splenic hilar lymph node (No. 10) metastasis, the oncologic benefit of splenectomy remains controversial, while its association
Tsutomu Hayashi, Takaki Yoshikawa
wiley   +1 more source

Selective activation of PPARα by pemafibrate mitigates peritoneal inflammation and fibrosis through suppression of NLRP3 inflammasome and modulation of inflammation

Scientific Reports
Peritoneal inflammation and fibrosis remain major challenges to the long-term maintenance of peritoneal dialysis. Pemafibrate, a selective peroxisome proliferator-activated receptor α (PPARα) modulator, has been implicated in the management of fibrosis ...
Yutaka Shinkai, Kensuke Sasaki, Ryo Tamura, Takeshi Ike, Akira Takahashi, Yosuke Osaki, Naoki Ishiuchi, Yujiro Maeoka, Ayumu Nakashima, Takao Masaki   +9 more
doaj   +1 more source

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC).
Kenichiro Araki, Norio Kubo, Yuhei Miyasaka, Hayato Ikota, Ryo Muranushi, Mariko Tsukagoshi, Takamichi Igarashi, Masahiko Okamoto, Tatsuya Ohno, Ken Shirabe   +9 more
wiley   +1 more source

Experimental research advances of treating peritoneal dialysis-related peritoneal fibrosis with traditional Chinese medicine

Linchuang shenzangbing zazhi, 2022
Peritoneal fibrosis is the most common type of peritoneal lesions in peritoneal dialysis （PD） patients. It is characterized by abnormal production of extracellular matrix protein， thickening of peritoneal interstitial connective tissue， damage of ...
Liu Qian-cheng, Liu Xin, Wu Min-hua, Zhou Shao-hua, Meng Li-feng   +4 more
doaj  

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

Annals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source