Results 31 to 40 of about 408,139 (189)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

SAHA Suppresses Peritoneal Fibrosis in Mice [PDF]

, 2015
Objective: Long-term peritoneal dialysis causes peritoneal fibrosis in submesothelial areas. However, the mechanism of peritoneal fibrosis is unclear. Epigenetics is the mechanism to induce heritable changes without any changes in DNA sequences.
Kitamura, Mineaki, Nishino, Tomoya, Io, Kumiko, Kohno, Shigeru, Koji, Takehiko, Obata, Yoko   +5 more
core   +2 more sources

Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis

Frontiers in Pharmacology, 2022
Aim: Peritoneal dialysis is a common renal replacement method for end-stage renal disease. Long-term peritoneal dialysis leads to peritoneal dialysis-related peritoneal fibrosis, which leads to a cessation of treatment.
Fang Li, Yu Wang, Jianwei Tian, Zhanmei Zhou, Wei Yin, Xianhui Qin, Huizhen Wang, Tao Zeng, Aiqing Li, Jianping Jiang   +9 more
doaj   +1 more source

Pharmacologic Inhibition of Histone Deacetylase 6 Prevents the Progression of Chlorhexidine Gluconate-Induced Peritoneal Fibrosis by Blockade of M2 Macrophage Polarization

Frontiers in Immunology, 2022
Peritoneal fibrosis contributes to ultrafiltration failure in peritoneal dialysis (PD) patients and thus restricts the wide application of PD in clinic.
Yingfeng Shi, Jinqing Li, Hui Chen, Yan Hu, Lunxian Tang, Xun Zhou, Min Tao, Zexin Lv, Si Chen, Andong Qiu, Na Liu   +10 more
doaj   +1 more source

Comparative Analysis of Gut Microbiota in Incident and Prevalent Peritoneal Dialysis Patients With Peritoneal Fibrosis, Correlations With Peritoneal Equilibration Test Data in the Peritoneal Fibrosis Cohort [PDF]

Therapeutic Apheresis and Dialysis
Jizhong Shen
exaly   +2 more sources

Therapeutic Targeting of GSK3β-Regulated Nrf2 and NFκB Signaling Pathways by Salvianolic Acid A Ameliorates Peritoneal Fibrosis

Frontiers in Medicine, 2022
Peritoneal fibrosis is a devastating complication in patients undergoing peritoneal dialysis, with no definite therapy yet available. Salvia miltiorrhiza and its major active component Salvianolic acid A (Sal A) have demonstrated a beneficial effect in ...
Fan Zhou, Fan Zhou, Lan Yao, Xiaoqing Lu, Yubao Li, Xingmin Han, Xingmin Han, Pei Wang   +7 more
doaj   +1 more source

Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats. [PDF]

PLoS ONE, 2012
The benefits of long-term peritoneal dialysis (PD) in patients with end-stage renal failure are short-lived due to structural and functional changes in the peritoneal membrane.
Juan Pérez-Martínez, Francisco C Pérez-Martínez, Blanca Carrión, Jesús Masiá, Agustín Ortega, Esther Simarro, Syong H Nam-Cha, Valentín Ceña   +7 more
doaj   +1 more source

Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6

Stem Cell Research & Therapy, 2021
Background Life-long peritoneal dialysis (PD) as a renal replacement therapy is limited by peritoneal fibrosis. Previous studies showed immunomodulatory and antifibrotic effects of adipose-derived mesenchymal stem cells (ADSCs) on peritoneal fibrosis ...
Chih-Yu Yang, Pu-Yuan Chang, Jun-Yi Chen, Bo-Sheng Wu, An-Hang Yang, Oscar Kuang-Sheng Lee   +5 more
doaj   +1 more source

Saikosaponin D Inhibits Peritoneal Fibrosis in Rats With Renal Failure by Regulation of TGFβ1/ BMP7 / Gremlin1/ Smad Pathway

Frontiers in Pharmacology, 2021
Peritoneal dialysis (PD) can improve the quality of life of patients with kidney disease and prolong survival. However, peritoneal fibrosis can often occur and lead to PD withdrawal.
Liu Ruiqi, Pei Ming, Su Qihang, Lei Yangyang, Chen Junli, Lin Wei, Gao Chao, Liu Xinyue, Yang Kang, Yang Hongtao   +9 more
doaj   +1 more source

Brahma-related gene 1 acts as a profibrotic mediator and targeting it by micheliolide ameliorates peritoneal fibrosis

Journal of Translational Medicine, 2023
Background Progressive peritoneal fibrosis is a worldwide public health concern impacting patients undergoing peritoneal dialysis (PD), yet there is no effective treatment.
Shuting Li, Congwei Luo, Sijia Chen, Yiyi Zhuang, Yue Ji, Yiqun Zeng, Yao Zeng, Xiaoyang He, Jing Xiao, Huizhen Wang, Xiaowen Chen, Haibo Long, Fenfen Peng   +12 more
doaj   +1 more source