Peritoneal dialysis and peritoneal fibrosis: molecular mechanisms, risk factors and prospects for prevention [PDF]
Український Журнал Нефрології та Діалізу, 2022 Peritoneal dialysis (PD) leads to structural and functional changes in the peritoneal membrane, the endpoint of which is peritoneal fibrosis. Peritoneal fibrosis is diagnosed in 50% and 80% of PD patients within 1 and 2 years of treatment initiation ...
N. Stepanova, L. Snisar, O. Burdeyna
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Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis [PDF]
Scientific ReportsOne of the most common causes of peritoneal dialysis withdrawal is ultrafiltration failure which is characterized by peritoneal membrane thickening and fibrosis.
Akie Ikushima +11 more
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Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis [PDF]
International Journal of Molecular SciencesThe characteristic feature of chronic peritoneal damage in peritoneal dialysis (PD) is a decline in ultrafiltration capacity associated with pathological fibrosis and angiogenesis.
Makoto Yamaguchi +2 more
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Linchuang shenzangbing zazhi, 2021 Peritoneal dialysis is one of renal replacement therapies for patients with end-stage renal disease（ESRD）.Peritoneal dialysis-related peritoneal fibrosis is the most important reason for withdrawing peritoneal dialysis in ESRD patients.Previous studies ...
Liao Meng +3 more
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Preventing Peritoneal Dialysis-Associated Fibrosis by Therapeutic Blunting of Peritoneal Toll-Like Receptor Activity [PDF]
Frontiers in Physiology, 2018 Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis.
Anne-Catherine Raby, Mario O. Labéta
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Therapeutic mechanism of baicalein in peritoneal dialysis-associated peritoneal fibrosis based on network pharmacology and experimental validation [PDF]
Frontiers in Pharmacology, 2023 Baicalein (5,6,7-trihydroxyflavone) is a traditional Chinese medicine with multiple pharmacological and biological activities including anti-inflammatory and anti-fibrotic effects.
Xiaohui Lu +21 more
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A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis [PDF]
Frontiers in Physiology, 2023 Peritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with
Jin’e Li +3 more
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Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions [PDF]
Frontiers in Immunology, 2021 Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins leading to progressive thickening of the submesothelial compact zone of the peritoneal membrane.
Michela Terri +11 more
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Experimental systems to study the origin of the myofibroblast in peritoneal fibrosis
Kidney Research and Clinical Practice, 2016 Peritoneal fibrosis is one of the major complications occurring in long-term peritoneal dialysis patients as a result of injury. Peritoneal fibrosis is characterized by submesothelial thickening and fibrosis which is associated with a decline in ...
Manreet Padwal, Peter J. Margetts
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Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis. [PDF]
PLoS ONE, 2018 Transforming growth factor-β1 (TGF-β1) is a major mediator of peritoneal fibrosis and reportedly affects expression of the H3K4 methyltransferase, SET7/9.
Ryo Tamura +6 more
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