Results 21 to 30 of about 408,139 (189)

Inhibition of PI3K/AKT/mTOR Signalling Pathway Activates Autophagy and Suppresses Peritoneal Fibrosis in the Process of Peritoneal Dialysis

Frontiers in Physiology, 2022
Peritoneal dialysis (PD) is an important part of replacement therapy for kidney failure. However, long-term PD treatment can cause peritoneal fibrosis. Autophagy may be involved in the pathological mechanism of peritoneal fibrosis (PF).
Miao Jia, Hong Qiu, Lihua Lin, Shun Zhang, Damei Li, Donghua Jin   +5 more
doaj   +3 more sources

Zinc: a potential star for regulating peritoneal fibrosis [PDF]

Frontiers in Pharmacology
Peritoneal dialysis (PD) is a commonly used renal replacement therapy for patients with end-stage renal disease (ESRD). During PD, the peritoneum (PM), a semi-permeable membrane, is exposed to nonbiocompatible PD solutions. Peritonitis can occur, leading
Jian Li, Xinyang Li, Yangwei Wang, Lingfei Meng, Wenpeng Cui   +4 more
doaj   +2 more sources

Peritoneal Dialysis -Associated Fibrosis: Emerging Mechanisms and Therapeutic Opportunities

Frontiers in Pharmacology
Peritoneal Dialysis (PD) requires a healthy and functional peritoneal membrane for adequate ultrafiltration and fluid balance, making it a vital treatment for patients with end-stage renal disease (ESRD). The spectrum of PD-associated peritoneal fibrosis
Narayan Prasad, Saurabh Chaturvedi, Harshit Singh, Mary Priyanka Udumula, Atul Rawat, Meyyappan Jeyakumar, Akhilesh Jaiswal, Sachin Kumar, Vikas Agarwal   +8 more
doaj   +2 more sources

Exosomes derived from bone marrow mesenchymal stem cells ameliorate peritoneal fibrosis induced by high glucose peritoneal dialysate solution in mice

陆军军医大学学报, 2022
Objective To investigate the role of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) in peritoneal fibrosis induced by high glucose peritoneal dialysis in mice.
WANG Xiaoyue, AI Qingli, YU Fang, LUO Jia, WANG Liming   +4 more
doaj   +1 more source

Loss of JNK-Associated Leucine Zipper Protein Promotes Peritoneal Dialysis-Related Peritoneal Fibrosis

Kidney Diseases, 2022
Background: Peritoneal dialysis-related peritoneal fibrosis is the leading cause of peritoneal ultrafiltration failure. Multitude factors and pathological processes have been implicated in peritoneal fibrosis development and progression, whereas the ...
Maoqing Tian, Lu Zhang, Yujuan Wang, Meili Deng, Cancan Peng, Wei Liang, Guohua Ding, Bo Shen, Huiming Wang   +8 more
doaj   +1 more source

Ameliorative role of SIRT1 in peritoneal fibrosis: an in vivo and in vitro study

Cell & Bioscience, 2021
Background Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function of peritoneum caused by peritoneal fibrosis not only limits the curative efficacy of PD and but affects the prognosis of ...
Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Yage Zhang, Xinxin Pang, Lin Tang   +7 more
doaj   +1 more source

Suppression of Peritoneal Fibrosis by Sonoporation of Hepatocyte Growth Factor Gene-Encoding Plasmid DNA in Mice

Pharmaceutics, 2021
Gene therapy is expected to be used for the treatment of peritoneal fibrosis, which is a serious problem associated with long-term peritoneal dialysis. Hepatocyte growth factor (HGF) is a well-known anti-fibrotic gene.
Koyo Nishimura, Koki Ogawa, Maho Kawaguchi, Shintaro Fumoto, Hidefumi Mukai, Shigeru Kawakami   +5 more
doaj   +1 more source

SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway

Stem Cell Research & Therapy, 2020
Introduction Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Combination therapies are emerging as a promising treatment for tissue damage.
Yanhong Guo, Liuwei Wang, Rong Gou, Yulin Wang, Xiujie Shi, Xinxin Pang, Lin Tang   +6 more
doaj   +1 more source

Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization

Frontiers in Immunology, 2023
BackgroundPeritoneal dialysis (PD) is an effective replacement therapy for end-stage renal disease patients. However, long-term exposure to peritoneal dialysate will lead to the development of peritoneal fibrosis.
Xun Zhou, Hui Chen, Yingfeng Shi, Jinqing Li, Xiaoyan Ma, Lin Du, Yan Hu, Min Tao, Qin Zhong, Danying Yan, Shougang Zhuang, Shougang Zhuang, Na Liu   +12 more
doaj   +1 more source

Blockade of prostaglandin E2 receptor 4 ameliorates peritoneal dialysis-associated peritoneal fibrosis

Frontiers in Pharmacology, 2022
Inflammatory responses in the peritoneum contribute to peritoneal dialysis (PD)-associated peritoneal fibrosis. Results of our previous study showed that increased microsomal prostaglandin E synthase-1-mediated production of prostaglandin E2 (PGE2 ...
Qimei Luo, Mi Liu, Yanhong Tan, Jinzhong Chen, Wei Zhang, Shaoxin Zhong, Jianyi Pan, Qingkun Zheng, Lewei Gong, Lijuan Su, Zhanjun Jia, Xianrui Dou   +11 more
doaj   +1 more source