Results 31 to 40 of about 86,999 (210)

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Prevention of peritonitis after cystectomy in patients with bladder neoplasms

Kazan medical journal, 1981
Analysis of the immediate results of cystectomy in 159 patients showed that, in order to prevent peritonitis after cystectomy with ureterocoloanastomosis, it is advisable to combine intraoperative novocaine blockade of the nervous intermesenteric tract with ureter transplantation into the sigmoid part of the intestine below the sacro-lumbar joint or ...
E. N. Sitdykov, I. A. Salikhov, M. E. Sitdykova, S. M. Akhmetova   +3 more
openaire   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Mid‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter retrospective cohort study compared mid‐term oncological outcomes between intracorporeal anastomosis (IA) and extracorporeal anastomosis (EA) in minimally invasive colectomy for colon cancer using propensity score–matched data from 2018 to 2022.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Shinya Hamasu, Keita Hanada, Kenji Kawada, Teppei Murakami, Satoshi Nagayama, Kazutaka Obama   +9 more
wiley   +1 more source

Prognostic Significance of Portal Vein Tumor Thrombus in Pancreatic Ductal Adenocarcinoma Treated With Chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To examine the significance of portal vein tumor thrombus (PVTT) as a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC) treated with chemoradiotherapy (CRT) followed by surgery. Methods The study retrospectively examined 313 patients with borderline resectable (BR) or locally advanced (LA) PDAC who underwent CRT ...
Aoi Hayasaki, Motonori Nagata, Miki Usui, Hiroshi Imai, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno   +9 more
wiley   +1 more source

Comparison Between Upfront Surgery and Preoperative Chemotherapy for CY1P0 Gastric Cancer: A Japanese Sub‐Analysis of CONVO‐GC‐1

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Radical gastrectomy, followed by adjuvant chemotherapy has been a common practice in Japan for peritoneal lavage cytology‐positive (CY1) but peritoneal dissemination‐negative (P0) stage IV gastric cancer. This study aimed to clarify the differences in treatment outcomes between upfront surgery and preoperative chemotherapy, followed
Kenichiro Furukawa, Itaru Yasufuku, Hironori Ishigami, Masahiro Yura, Takanobu Yamada, Shigeaki Baba, Takeshi Kubota, Erina Nagai, Seito Fujibayashi, Mitsumasa Yoshida, Takahiro Kinoshita, Nobuhisa Matsuhashi, Masanori Terashima   +12 more
wiley   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Short‐Term Outcomes of Robot‐Assisted Versus Laparoscopic Colectomy for Colon Cancer: A Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue, Yujiro Nishizawa, Yoshinori Kagawa, Masahiro Hashimoto, Shinya Kato, Yoshihiro Morimoto, Taishi Hata, Makoto Fujii, Masaaki Motoori, Kazumasa Fujitani   +9 more
wiley   +1 more source

Real‐World Data of Retroperitoneal Tumor Surgeries Performed by Gastroenterological Surgeons in Japan: Analysis Based on the National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Retroperitoneal tumors (RPTs) are rare and anatomically complex neoplasms, for which surgery remains the mainstay of treatment. However, real‐world data on their surgical management in Japan have been limited. Objective To describe the clinical characteristics and short‐term outcomes of patients undergoing resection for RPTs in ...
Keisuke Kurimoto, Hiroyuki Yamamoto, Masaki Sunagawa, Yoshiki Kajiwara, Hiroshi Hasegawa, Hideki Ueno, Ken Shirabe, Mitsuro Kanda, Tomoki Ebata, Yukihiro Yokoyama   +9 more
wiley   +1 more source