Results 51 to 60 of about 91,737 (262)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Case Report: Insights into multiple cases of Pseudomyxoma peritonei

Frontiers in Gastroenterology
As a rare peritoneal malignant tumor, Pseudomyxoma peritonei (PMP) is a challenge in the field of surgery and oncology due to its complex pathological mechanism and difficult clinical management.
HanJie Chu, XiaoBiao Song
doaj   +1 more source

Which patient is going to benefit from surgical cytoreduction with intraperitoneal chemotherapy (for manifest peritoneal metastases)?

Current Issues in Pharmacy and Medical Sciences, 2017
The gastric cancer with peritoneal metastases still represents a serious problem in the oncological surgery, whereas the peritoneal metastases arising from colorectal cancer can be successfully treated using a multimodal therapy concept consisting of ...
Blaj Sebastian, Piso Pompiliu
doaj   +1 more source

Treatment of peritoneal surface neoplasms with intraperitoneal chemotherapy in hyperthermia [PDF]

Polish Journal of Public Health, 2015
Abstract Effective treatment of peritoneal surface neoplasms is possible through the simultaneous use of cytoreductive surgery with intraperitoneal chemotherapy in hyperthermia. It is successfully performed in patients with peritoneal pseudomyxoma, mesothelioma, as well as a limited and resectable peritoneal carcinomatosis in the course
Jerzy Mielko, Bogumila Ciaseł, Magdalena Skórzewska, Robert Sitarz, Andrzej Kurylcio, Wojciech P. Polkowski   +5 more
openaire   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Peritoneal Keratin Granulomatosis Associated with Endometrioid Adenocarcinoma of the Uterine Corpus in a Woman with Polycystic Ovaries: A Potential Pitfall—A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology, 2017
Peritoneal keratin granulomatosis is a rare condition included under granulomatous lesions of the peritoneum. It can be secondary to neoplasms of the female genital tract and can mimic carcinomatosis intraoperatively. A case of a 40-year-old woman with a
Helen J. Trihia, Maria Papazian, Natasa Novkovic, John Provatas, Sotiria Tsangouri, Dimitrios C. Papatheodorou   +5 more
doaj   +1 more source

Peritoneal metastatic mixed adenoneuroendocrine carcinoma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report [PDF]

Annals of Coloproctology
A 61-year-old man presented with abdominal distension without any symptoms. On colonoscopy and computed tomography findings, it was clinically diagnosed as peritoneal metastasis of sigmoid colon cancer, and diagnostic laparoscopy was performed.
Sungchul Lee, Euitae Kim, Dong-Guk Park
doaj   +1 more source

The role of chemotherapy in the treatment of advanced appendiceal cancers: summary of the literature and future directions

Therapeutic Advances in Medical Oncology, 2022
Appendiceal cancer is rare and encompasses a diverse group of tumours ranging from low-grade appendiceal mucinous neoplasms to high-grade adenocarcinomas.
Madeleine C. Strach, Sarah Sutherland, Lisa G. Horvath, Kate Mahon   +3 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source