Results 91 to 100 of about 31,079 (213)

Perivascular Adipose Tissue, Potassium Channels, and Vascular Dysfunction [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Perivascular adipose tissue has been recognized unequivocally as a major player in the pathology of metabolic and cardiovascular diseases. Through its production of adipokines and the release of other thus far unidentified factors, this recently discovered adipose tissue modulates vascular regulation and the myogenic response.
Jean-Yves, Tano, Johanna, Schleifenbaum, Maik, Gollasch   +2 more
openaire   +2 more sources

Relationship of Visceral Adipose Tissue With Dilated Perivascular Spaces

Frontiers in Neuroscience, 2021
BackgroundDilated perivascular spaces (dPVS) are considered to be a type of cerebral small vessel disease (CSVD) as well as an important part of the glymphatic system. Although obesity has been shown to play a significant role in the development of CSVD,
Yunli Qi, Yunli Qi, Mengqi Lin, Yunjun Yang, Yanxuan Li, Yanxuan Li   +5 more
doaj   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering.

PLoS ONE, 2017
For over 15 years, human subcutaneous adipose tissue has been recognized as a rich source of tissue resident mesenchymal stem/stromal cells (MSC). The isolation of perivascular progenitor cells from human adipose tissue by a cell sorting strategy was ...
Aaron W James, Xinli Zhang, Mihaela Crisan, Winters R Hardy, Pei Liang, Carolyn A Meyers, Sonja Lobo, Venu Lagishetty, Martin K Childers, Greg Asatrian, Catherine Ding, Yu-Hsin Yen, Erin Zou, Kang Ting, Bruno Peault, Chia Soo   +15 more
doaj   +1 more source

Human blood-vessel-derived stem cells for tissue repair and regeneration [PDF]

, 2012
Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood ...
Chen, CW, Corselli, M, Huard, J, Péault, B   +3 more
core   +3 more sources

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Crosstalk between perivascular adipose tissue and blood vessels [PDF]

Current Opinion in Pharmacology, 2010
Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function.
Srinivas, Rajsheker, David, Manka, Andra L, Blomkalns, Tapan K, Chatterjee, Lynn L, Stoll, Neal L, Weintraub   +5 more
openaire   +2 more sources

Adipocytes, aldosterone and obesity-related hypertension [PDF]

, 2016
Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions.
Friederich-Persson, Malou, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M., White, Anna   +3 more
core   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis

Frontiers in Physiology, 2018
Traditionally, it is believed that white adipose tissues serve as energy storage, heat insulation, and mechanical cushion, whereas non-shivering thermogenesis occurs in brown adipose tissue.
Kimie Tanaka, Masataka Sata
doaj   +1 more source