Defining the lineage of thermogenic perivascular adipose tissue [PDF]
Nature Metabolism, 2021 Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with large blood vessels, corresponding to perivascular adipose tissue (PVAT).
Anthony R. Angueira +13 more
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Hydrogen Sulfide in the Adipose Tissue—Physiology, Pathology and a Target for Pharmacotherapy
Molecules, 2016 Hydrogen sulfide (H2S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase (CSE). Several studies have demonstrated that H2S is involved in adipogenesis, that is the differentiation of preadipocytes to adipocytes, most likely by ...
Jerzy Bełtowski +1 more
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Nerve-perivascular fat communication as a potential influence on the performance of blood vessels used as coronary artery bypass grafts. [PDF]
, 2017 Perivascular fat, the cushion of adipose tissue surrounding blood vessels, possesses dilator, anti-contractile and constrictor actions. The majority of these effects have been demonstrated in vitro and may depend on the vessel and/or the experimental ...
Dashwood, MR, Loesch, A
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Hypothesis: ‘Vasocrine’ signalling from perivascular fat - a mechanism linking insulin resistance and vascular disease [PDF]
, 2005 Adipose tissue expresses cytokines which inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation to insulin. We propose a vasoregulatory role for local deposits of fat around the
Eringa, E. +2 more
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Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise [PDF]
Cardiovascular Drugs and Therapy, 2021 Abstract Purpose Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic cation transporter 3 (OCT3) and β3-adrenoceptor-mediated ...
Saxton, SN +5 more
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Adipose tissue secretory profile and cardiometabolic risk in obesity
Endocrine and Metabolic Science, 2020 Adipose tissue is not only an energy storage but also the largest endocrine organ in the body. The protein factors secreted from adipose tissue are collectively referred to as adipokines.
Pengcheng Zhang, Daniels Konja, Yu Wang
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Ectopic fat depots: physiological role and impact on cardiovascular disease continuum
Russian Open Medical Journal, 2022 Obesity is a non-infectious pandemic. The visceral distribution of adipose tissue is a significant factor in the development of cardiovascular diseases and their complications.
Anna E. Bragina +7 more
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Imbalance between pro and anti-oxidant mechanisms in perivascular adipose tissue aggravates long-term high-fat diet-derived endothelial dysfunction [PDF]
, 2014 Background: The hypothesis of this study is that long-term high-fat diets (HFD) induce perivascular adipose tissue (PVAT) dysfunction characterized by a redox imbalance, which might contribute to aggravate endothelial dysfunction in obesity.
Arribas, Silvia M. +8 more
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Attenuated adiposopathy in perivascular adipose tissue compared with subcutaneous human adipose tissue [PDF]
The American Journal of Surgery, 2013 We hypothesized that human perivascular and subcutaneous adipose tissues hold distinct phenotypic signatures. We also evaluated the impact of clinical parameters on the adipose phenotype. Our overall goal is to understand the determinants of adipose biology so that this tissue can be manipulated therapeutically to lessen peripheral vascular disease ...
Christine R, Mauro +8 more
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Thoracic Periaortic and Visceral Adipose Tissue and Their Cross-sectional Associations with Measures of Vascular Function [PDF]
, 2014 Objective: Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) are associated with vascular function. Design and
Benjamin, Emelia J. +12 more
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