Results 81 to 90 of about 31,079 (213)
Interdisciplinary Medicine, EarlyView.This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen +12 more
wiley +1 more source
Perivascular adipose tissue and atherosclerosis: phenotypic features and therapeutic potential
Атеросклероз, 2020 This review is devoted to the analysis of data on the study of the endocrine function of perivascular adipose tissue (PVAT), its role in the synthesis and secretion of adipocyte hormones – adipokines (leptin, adiponectin, resistin).
D. A. Borodkina +4 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 Most blood vessels are surrounded by adipose tissues known as perivascular adipose tissue (PVAT). Emerging experimental data have implicated the potential involvement of PVAT in the pathogenesis of cardiovascular disease: PVAT might be a source of ...
Yusuke Adachi +2 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu +5 more
wiley +1 more source
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity [PDF]
, 2015 Fibrosis is a common disease process in which profibrotic cells disturb organ function by secreting disorganized extracellular matrix (ECM). Adipose tissue fibrosis occurs during obesity and is associated with metabolic dysfunction, but how profibrotic ...
Dozmorov, Mikhail G. +6 more
core +3 more sources
Andrology, EarlyView.Abstract Background Penile sexual sensation relies on intricate neural structures that remain incompletely characterized. Immunohistological insights into their development and organization can enhance understanding of penile neuroanatomy and function, while optimizing surgical outcomes.
Alfonso Cepeda‐Emiliani +6 more
wiley +1 more source
Macrophage Immunometabolism in Perivascular Adipose Tissue [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Hong Shi, Ha Won Kim, Neal L. Weintraub
openaire +2 more sources
Perivascular Adipose Tissue [PDF]
Reproductive Sciences, 2015 Perivascular adipose tissue (PVAT) contributes to vasoregulation. The role of this adipose tissue bed in pregnancy has not been examined. Here, we tested the hypothesis that PVAT in pregnant rats decreases resistance artery tone. Mesenteric arteries from nonpregnant (NP) and late pregnant (LP) rats were exposed to phenylephrine (PHE) or KCl in the ...
Stephanie E, Mann +3 more
openaire +2 more sources
Life(1) Background: Systemic inflammation stands as a well-established risk factor for ischemic cardiovascular disease, as well as a contributing factor in the development of cardiac arrhythmias, notably atrial fibrillation.
Domenico Tuttolomondo +19 more
doaj +1 more source
Infection control in the brain and the eye
Acta Ophthalmologica, EarlyView.Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester +2 more
wiley +1 more source