Results 91 to 100 of about 1,329,154 (252)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Income Asymmetries and the Permanent Income Hypothesis [PDF]
Within the context of the Permanent Income Hypothesis (PIH), the predictions for consumption depend crucially upon the process for income. In this paper, we consider an unobserved components model that allows for both asymmetric transitory movements and ...
Juan Urquiza
core
Clinical and genetic insights into congenital hypothyroidism with gland-in-situ
Trends in PediatricsObjective: This study aimed to investigate the genetic etiology of congenital hypothyroidism (CH) with gland-in-situ (GIS) by screening 23 candidate genes using next-generation sequencing (NGS) in a cohort of Turkish patients.
Fatma Dursun +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2001 Bureau permanent de l'OUA a Bruxelles. (2001-07). Rapport d'activités pour la période allant de décembre 2000 a juin 2001. Pendant le periode sous examen, le Bureau Permanent de l'OUA a Bruxelles a mené des activités dans les domains économiques ...
Bureau Permanent de l'OUA a Bruxelles
core +1 more source
Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗThree composite surface soil samples were collected and net surficial charges of the soil were estimated using potentiometric titration curves. Cells for electricity generation were prepared.
Mohammed A. Fayyadh
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Journal of Research in Medical Sciences, 2013 Background: Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the intelligence quotient (IQ) of children with CH and the effect of diagnostic and treatment variables on it were investigated during the CH screening program ...
Seyed Badredin Najmi +4 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source