Results 61 to 70 of about 49,772 (296)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cryogenic motor with two radial AMBs in liquid nitrogen

AIP Advances, 2021
A cryogenic motor with active magnetic bearings (AMBs) which works in liquid nitrogen is discussed in this paper. The cryogenic motor is composed of two AMBs, four displacement sensors, a permanent magnet (PM) motor, etc.
M. Komori, H. Kato, K. Asami, N. Sakai
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Vertical permanent displacement diagram of L-H40-#2.

(a) Vertical permanent displacement of LSFC composite slab; (b) Vertical permanent displacement of W-shaped steel plate.
Lei Wang (6656), Jinbo Chen (295024), Shuwang Yang (14194271), Qiang Xu (71522), Minghao Yang (11288337), Bowen Liu (2009599), Linghui Meng (2494408), Zhenhui Zhang (847340)   +7 more
core   +1 more source

Seismic Response of a Large-Span Steel Truss Arch Bridge under Nonuniform Near-Fault Ground Motions

Buildings
The ground motion in the near-fault region of an earthquake is characterized by exceptional energy levels, powerful velocity impulses, substantial spatial variability, and notable permanent displacement.
Zhen Liu, Xingliang Ma, Junlin Lv
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Review of fault models for reproducing and predicting strong ground motions and permanent displacements—findings in the 2016 Kumamoto earthquake

Japan Architectural Review
For accurate evaluation of the impact of earthquakes to structures in the vicinity of the earthquake faults, it has been required to develop appropriate calculation methods for short‐ and long‐period ground motions and permanent displacements.
Kazuo Dan
doaj   +1 more source

Permanent displacement of slopes under multi-point earthquake ground motions considering site effects

Yantu gongcheng xuebao
The nonlinear dynamic response of slope soils caused by seismic motion may lead to inconsistent time histories of seismic acceleration at different positions of a slope.
SONG Jian1, 2 , PAN Yuhang2, LU Zhuxi2, JI Jian1, 2, ZHANG Fei1, 2, GAO Yufeng1, 2
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source