Results 61 to 70 of about 45,406 (263)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Deprem Yükleri Altında Kalıcı Şev Deplasmanlarının Tahmini

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2014
Dinamik yükleme altındaki şevlerin stabilitesi genel olarak yarı-statik analiz yöntemi kullanılarak incelenir. Bu yöntem, belirli bir güvenlik katsayısını dikkate almakla birlikte, oluşan kalıcı deplasmanlar hakkında bir bilgi vermemektedir.
Deniz Ülgen, H. Kürşat Engin
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Energy Method for Evaluating Earthquake Induced Permanent Displacement of Soil Slopes

工程科学与技术, 2010
:Since the permanent displacement induced by earthquake can be regarded as an effective criterion for stability estimation and anti-seismic design of slopes, a new method for evaluating the displacement and improve its estimating accuracy was proposed ...
Xu Guang-xing
doaj  

Seismic dynamic response analysis for tunnels considering coseismic displacement

Yantu gongcheng xuebao
Fault dislocation is a form of dynamic impact load that induces permanent deformation of the stratum in the vicinity of the fault. Based on the finite-fault source and crustal velocity model, coseismic displacement is computed according to the layered ...
FENG Jun1, 2 , ZHAO Boming1, 2 , WANG Zijun1, 2
doaj   +1 more source

Quasi-Equilibrium Stress Zone with Residual Displacement Causing Permanent Slippage in Shrink-Fitted Sleeve Rolls

Metals, 2018
Rolling back-up rolls require high fracture toughness, particularly in the shaft portion, and high-hardness in the sleeve portion. The rolls are classified into two types; one is an integrated type and the other is a shrink-fitted type consisting of a ...
Nao-Aki Noda, Hiromasa Sakai, Yoshikazu Sano, Yasushi Takase, Yutaro Shimoda   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Development of Permanent Displacement Model for Seismic Mountain Slope

Journal of the Korean Geotechnical Society, 2015
Empirical seismic displacement equations based on the Newmark sliding block method are widely used to develop seismic landslide hazard map. Most proposed equations have been developed for embankments and landfills, and do not consider the dynamic response of sliding block.
Jong-Hoo Lee, Duhee Park, Jae-Kwang Ahn, Inn-Joon Park   +3 more
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Bayesian network based probabilistic approach for uncertainty analysis of earthquake induced landslides

Soils and Foundations
In this study, a unique approach is used to calculate the likelihood of the safety factor and permanent displacement of natural slopes under earthquake shaking.
Tanmoy Das, Deepankar Choudhury
doaj   +1 more source