Results 181 to 190 of about 4,581 (261)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

International Journal of Cancer, EarlyView.
ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia, Daniele Santini, Marc R. Matrana, Marco Maruzzo, Ray Manneh Kopp, Lorenzo Antonuzzo, Sergio Bracarda, Deniz Tural, Giuseppe Procopio, Maria T. Bourlon, Orazio Caffo, Martin Ignacio Zapata Laguado, Massimo Di Maio, Brigida Anna Maiorano, Vincenza Conteduca, Sabrina Rossetti, Helga Lipari, Thomas Büttner, Mimma Rizzo, Yüksel Ürün, Carlo Messina, Fernando Sabino Marques Monteiro, Andrey Soares, Mattia Puglisi, Alice Principi, Eleonora Lai, Giulia Mammone, Marco Stellato, Ilaria Depetris, Tancredi Didier Bazan Russo, Isadora Yasbick Spricido, Camila Bobato Lara Gismondi, Francesco Massari, Nicola Pavan, Matteo Santoni, Tarek Taha   +35 more
wiley   +1 more source

Real‐World Experience With Multimodal Treatment of Resectable Stage II–III Non‐Small Cell Lung Cancer: A Single Institutional Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Neoadjuvant therapy has recently become an integral component of multimodal treatment for resectable lung cancer. However, real‐world data on perioperative morbidity and treatment adherence remain limited. This study aimed to assess the feasibility and safety of different neoadjuvant treatment approaches applied within daily clinical routine ...
Raffaella Griffo, Benedikt Niedermaier, Laura V. Klotz, Marc Schneider, Michael Allgäuer, Marc Kriegsmann, Romina M. Roesch, Lena Brendel, Henrike Deissner, Farastuk Bozorgmehr, Petros Christopoulos, Michael Thomas, Hauke Winter, Martin E. Eichhorn, Florian Eichhorn   +14 more
wiley   +1 more source

Multi‐command wearable magnetic human‐machine interface enabled by low‐noise sensing and time‐series deep learning

InfoScience, EarlyView.
This study integrates a wrist‐worn sensing platform based on a low‐noise planar Hall magnetoresistive sensor with time‐series deep learning to enable long‐range, single‐sensor, multi‐command gesture recognition with high accuracy. Further evaluations show reliable generalization across different days, previously unseen users, wearing‐position ...
Guannan Mu, Proloy Taran Das, Jan Schmidtpeter, Andreas Knüpfer, Rui Xu, Denys Makarov   +5 more
wiley   +1 more source

A Semi‐Automated Microfluidic Platform Employing Machine Learning Analysis to Study Adhesion Kinetics in Acute Myeloid Leukemia

Microscopy Research and Technique, EarlyView.
We have developed a semi‐automated shear flow platform using bright‐field optics and a machine‐learning analysis algorithm to dissect tumor‐microenvironment interactions. The algorithm quantifies the extent of adhesion at the single‐cell level and delivers consistent results within minutes instead of hours, facilitating high‐throughput analysis ...
Driti Ashok, Dennis Raith, Gabriel Kalweit, Maria Kalweit, Anusha Klett, Justus Duyster, Jonas Bermeitinger, Tanja Nicole Hartmann   +7 more
wiley   +1 more source

Mercury cycling during the last glacial period in Arctic Lake El'gygytgyn, NE Russia

Journal of Quaternary Science, EarlyView.
ABSTRACT Tectonic processes play a key role in the global mercury (Hg) cycle on geological timescales, by mobilising Hg from deep Earth reservoirs to the surface. These natural fluxes also introduce a dynamic component to the terrestrial Hg cycle that can interact with other environmental signals and influence Hg delivery to sedimentary records.
Alice R. Paine, Joost Frieling, Bernd Wagner, Martin Melles, Volker Wennrich, Tamsin A. Mather, Stuart A. Robinson, David M. Pyle   +7 more
wiley   +1 more source

Multicenter Study Results on Expanded Indications in Med‐EL Pediatric Cochlear Implant Population

The Laryngoscope, EarlyView.
ABSTRACT Objectives To demonstrate safety and efficacy of MED‐EL cochlear implants (CIs) in children aged < 12 months and in children aged 12–71 months with residual hearing. Methods This was a multicenter, nonrandomized, single‐subject, repeated‐measures study with prospective (N = 38; 26 < 12 months of age) and retrospective (N = 209; 70 < 12 months ...
Nancy M. Young, Denise Thomas, Stephen R. Hoff, Jeffrey D. Carron, Victoria B. Gonzalez, Chrisanda M. Sanchez, Ivette Cejas, Paul W. Bauer, Aimee J. Gross, Margaret E. Richter, Lisa R. Park, Kevin D. Brown   +11 more
wiley   +1 more source

Invention of the Flexible Fiberoptic Nasopharyngolaryngoscope: Perspectives From the East

The Laryngoscope, EarlyView.
The fiberoptic nasopharyngolaryngoscope was developed in 1967 by Drs. Masayuki Sawashima, Hajime Hirose, and Osamu Fujimura at the University of Tokyo's Research Institute of Logopedics and Phoniatrics (RILP), building on Dr. Shigeto Ikeda's 1962 fiberoptic bronchoscope during Japan's postwar surge in technological innovation.
Carolyn J. Khoury, Rumi Ueha, Tyler G. Chan, Katherine Tai, Peak Woo, Hiroshi Imagawa, Kenji Kondo, Anaïs Rameau   +7 more
wiley   +1 more source

Raman‐Enabled Platicon Microcomb and Stokes Soliton in 4H‐SiC Microresonator

Laser &Photonics Reviews, EarlyView.
We harness Raman gain in a silicon carbide microresonator to enable efficient platicon microcomb generation in the normal‐dispersion regime. The resulting platicon spans 1500–1700 nm with a pump‐to‐comb conversion efficiency up to 56%. Simultaneous excitation of a Stokes soliton within the same mode family further broadens the Raman–Kerr microcomb ...
Jingwei Li, Ruixuan Wang, Qing Li
wiley   +1 more source

Staged Bilateral Magnetic Resonance‐Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Unilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.
Nima Norbu Sherpa, Andrea Gonzalez Lezana, Gabriela Prilip, Kenji Fukutome, Nathan J. Pertsch, Ruth Reeve, Nadège Bault, Elsa Fouragnan   +7 more
wiley   +1 more source