Results 161 to 170 of about 4,581 (261)

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

open access: yesEpilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi   +4 more
wiley   +1 more source

Artificial intelligence‐assisted categorization of interictal abnormalities in adult long‐term electroencephalographic monitoring: Comparable diagnostic accuracy with marked efficiency gain

open access: yesEpilepsia, EarlyView.
Abstract Objective Artificial intelligence (AI) classifies routine electroencephalograms (EEGs) with expert‐level accuracy, but interpretation of long‐term EEG monitoring (LTM) remains reliant on time‐intensive visual review. We evaluated whether autoSCORE, a clinically approved implementation of SCORE‐AI integrated into an EEG reader, achieves expert ...
Daniel Mansilla   +11 more
wiley   +1 more source

Repetitive clustered low‐voltage fast activity on intracranial electroencephalogram in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy: A candidate electroencephalographic biomarker study

open access: yesEpilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently recognized cause of drug‐resistant focal epilepsy. It is often magnetic resonance imaging‐negative or radiologically resembles focal cortical dysplasias, which makes recognition difficult and limits presurgical counseling ...
Vadym Gnatkovsky   +25 more
wiley   +1 more source

Impairment of ictal consciousness and psychosis in drug‐resistant focal epilepsy: A retrospective clinical cohort study

open access: yesEpilepsia, EarlyView.
Abstract Objective Psychoses of epilepsy (POE) affect up to 13% of patients with focal epilepsy. Whereas interictal risk factors are well documented, ictal correlates of POE remain poorly characterized. We hypothesized that an impairment of ictal consciousness on the Consciousness Seizure Scale (CSS), would be associated with POE.
Alexis Tarrada   +8 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

open access: yesEpilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

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