Results 171 to 180 of about 1,849,496 (250)
International Journal of Cancer, EarlyView.Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia +4 more
wiley +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Evidence to guide the treatment for patients with metastatic castration‐resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with tumor harboring HRR alterations, progressed on a prior androgen ...
Lorena Incorvaia +35 more
wiley +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
InfoScience, EarlyView.This study integrates a wrist‐worn sensing platform based on a low‐noise planar Hall magnetoresistive sensor with time‐series deep learning to enable long‐range, single‐sensor, multi‐command gesture recognition with high accuracy. Further evaluations show reliable generalization across different days, previously unseen users, wearing‐position ...
Guannan Mu +5 more
wiley +1 more source
Microscopy Research and Technique, EarlyView.We have developed a semi‐automated shear flow platform using bright‐field optics and a machine‐learning analysis algorithm to dissect tumor‐microenvironment interactions. The algorithm quantifies the extent of adhesion at the single‐cell level and delivers consistent results within minutes instead of hours, facilitating high‐throughput analysis ...
Driti Ashok +7 more
wiley +1 more source
Multicenter Study Results on Expanded Indications in Med‐EL Pediatric Cochlear Implant Population
The Laryngoscope, EarlyView.ABSTRACT Objectives To demonstrate safety and efficacy of MED‐EL cochlear implants (CIs) in children aged < 12 months and in children aged 12–71 months with residual hearing. Methods This was a multicenter, nonrandomized, single‐subject, repeated‐measures study with prospective (N = 38; 26 < 12 months of age) and retrospective (N = 209; 70 < 12 months ...
Nancy M. Young +11 more
wiley +1 more source
Invention of the Flexible Fiberoptic Nasopharyngolaryngoscope: Perspectives From the East
The Laryngoscope, EarlyView.The fiberoptic nasopharyngolaryngoscope was developed in 1967 by Drs. Masayuki Sawashima, Hajime Hirose, and Osamu Fujimura at the University of Tokyo's Research Institute of Logopedics and Phoniatrics (RILP), building on Dr. Shigeto Ikeda's 1962 fiberoptic bronchoscope during Japan's postwar surge in technological innovation.
Carolyn J. Khoury +7 more
wiley +1 more source
First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique
Mass Spectrometry Reviews, EarlyView.ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Unilateral magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy reduces tremor in essential tremor, yet disability often persists on the untreated side. The added benefit and safety of a staged contralateral lesion remain uncertain.
Nima Norbu Sherpa +7 more
wiley +1 more source
The Application of Telemedicine in Surgery
Med Research, EarlyView.This figure provides an overview of the content presented in this article. Telemedicine is integrated throughout the entire surgical workflow, with distinct applications across the preoperative, intraoperative, and postoperative phases. These applications are enabled by a suite of supporting technologies, while the associated implementation challenges ...
Yufan Yang +8 more
wiley +1 more source