Results 41 to 50 of about 9,941 (276)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Permanent structured cooperation in defence: building effective European armed forces. Bruges Political Research Papers No. 15, September 2010 [PDF]

, 2010
Sven Biscop and Jo Coelmont outline a concrete proposal to implement Permanent Structured Cooperation, the new mechanism introduced by the Lisbon Treaty in the area of the Common Security and Defence Policy.
Biscop, Sven, Coelmont, Jo.
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Permanence, Extinction and Periodic Solution of a Non-autonomous Cooperative System with Stage Structure

IOP Conference Series: Materials Science and Engineering, 2020
Abstract This paper studies a class of non-autonomous two-species cooperative system with stage structure. Some sufficient conditions on the boundedness, permanence, extinction, periodic solution of the system are established by using the comparison method.
Azhar Halik, Ahmadjan Muhammadhaji, Rouzimaimaiti Mahemuti   +2 more
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Constraints of Power Structures on EU Integration and Regulation of Military Procurement

European Papers, 2021
(Series Information) European Papers - A Journal on Law and Integration, 2021 6(1), 831-868 | Article | (Table of Contents) I. Introduction. - II. Legal structures of military integration and cooperation in the EU. - II.1.
Nathan Meershoek
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Permanent structured cooperation in defence of the obvious. Egmont Security Policy Brief No. 11, June 2010 [PDF]

, 2010
In their first Security Policy Brief on Permanent Structured Cooperation (No. 9 of March 2010), Sven Biscop and Jo Coelmont outlined a concrete proposal to implement this new defence mechanism introduced by the Lisbon Treaty.
Coelmont, Jo., Biscop, Sven.
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Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

The Problems of Permanent Structured Cooperation (PESCO) Implementation in the Framework of European Union Common Security and Defence Policy [PDF]

, 2019
The problems of Permanent structured cooperation (PESCO) implementation in the framework of European Union common security and defence policy.В данной статье рассматриваются причины и перспективы развития программы постоянного структурированного ...
Гусейнов, К. К., Guseinov, K.
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