Results 41 to 50 of about 3,380,119 (245)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

A Self-Learning Solution for Torque Ripple Reduction for Non-Sinusoidal Permanent Magnet Motor Drives Based on Artificial Neural Networks [PDF]

, 2013
This paper presents an original method, based on artificial neural networks, to reduce the torque ripple in a permanent-magnet non-sinusoidal synchronous motor.
WIRA, Patrick, OULD ABDESLAM, Djaffar, NGUYEN, Ngac Ky, MERCKLE, Jean, STURTZER, Guy, FLIELLER, Damien, Abdeslam, Djaffar Ould, Wira, Patrice   +7 more
core   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Permanent structured cooperation: the path to a common EU defence? / A. V. Zhdanok

, 2022
Секция 1. Актуальные аспекты внешней политики в современных международных отношенияхРассматриваются вопросы создания Постоянного структурированного сотрудничества (PESCO) в контексте геополитической ситуации.
Жданок, А. В.
core   +1 more source

NO RUMO DA "COMUNITARIZAÇÃO" DA SEGURANÇA E DEFESA DA UNIÃO EUROPEIA MEDIANTE A COOPERAÇÃO ESTRUTURADA PERMANENTE? HEADING FOR THE APPLICATION OF THE "COMMUNITY METHOD" TO SECURITY AND DEFENCE OF THE EUROPEAN UNION BY MEANS OF PERMANENT STRUCTURED COOPERATION?

Lex Humana, 2012
Resumo: O Tratado de Lisboa (na linha do malogrado Tratado Constitucional) veio, como término de várias iniciativas entretanto ocorridas, prever o mecanismo da cooperação estruturada permanente.
ABEL LAUREANO
doaj  

CSDP and the open method of coordination: Developing the EU's comprehensive approach to security [PDF]

Journal of Regional Security, 2017
How can we best describe the operation of the Common Security and Defence Policy (CSDP), and how can we improve policy-making in CSDP? The Open Method of Coordination (OMC) is predicated on the conviction that there are clear limits to the extent that ...
Sweeney Simon, Winn Neil
doaj  

Permanent structured cooperation in defence of the obvious. Egmont Security Policy Brief No. 11, June 2010 [PDF]

, 2010
In their first Security Policy Brief on Permanent Structured Cooperation (No. 9 of March 2010), Sven Biscop and Jo Coelmont outlined a concrete proposal to implement this new defence mechanism introduced by the Lisbon Treaty.
Coelmont, Jo., Biscop, Sven.
core