Results 161 to 170 of about 1,459,501 (364)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

open access: yesAdvanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins   +9 more
wiley   +1 more source

Twin Crystal Moiré Metasurfaces for Crossing Flat‐Band Transport

open access: yesAdvanced Functional Materials, EarlyView.
This study introduces twin crystal moiré metasurfaces, breaking in‐plane symmetry to enable reconfigurable acoustic wave manipulation. By adjusting the twin angle and interlayer twist angle, various combinations of hyperbolic, flat bands, and elliptic states can be synthesized in the system.
Shida Fan   +9 more
wiley   +1 more source

Micellar chromatographic partition coefficients and their application in predicting skin permeability

open access: yes
The major goal for physicochemical screening of pharmaceuticals is to predict human drug absorption, distribution, elimination, excretion and toxicity.
Shahzad, Yasser
core  

A study of asphalt permeability:Empirical permeability models

open access: yes, 2008
A study has been undertaken to investigate some important factors that influence the permeability of dense graded asphalt pavements. The aim of the study is to develop a data analysis procedure for finding empirical permeability relationships.
Nata-Atmadja, Andreas   +5 more
core  

Plasticity, Strength and Permeability of Reclaimed Asphalt Pavement and Lateritic Soil Blends [PDF]

open access: yes, 2014
This paper presents the results of laboratory evaluation of the effects of the addition of reclaimed asphalt pavement (RAP), to an A-2 lateritic soil, on the plasticity, strength and permeability of the soil.
Akinwumi, I. I.
core  

Development of a Three‐Axis Planar Hall Magnetoresistance Sensor Using a Superparamagnetic Nanoparticle‐Based Flux Guide

open access: yesAdvanced Functional Materials, EarlyView.
A printed superparamagnetic nanoparticle‐based flux guide enables the realization of a hysteresis‐free three‐axis magnetic sensor. This innovative architecture efficiently redirects out‐of‐plane fields to planar sensing elements, facilitating simultaneous vector detection without complex reset protocols.
Changyeop Jeon   +10 more
wiley   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng   +16 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

open access: yesAdvanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Shear-enhanced permeability and poroelastic deformation in unconsolidated sands

open access: yes, 2012
textHeavy oil production depends on the understanding of mechanical and flow properties of unconsolidated or weakly consolidated sands under different loading paths and boundary conditions. Reconstituted bitumen-free Athabasca oil-sands samples were used
Hamza, Syed Muhammad Farrukh
core  

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