Results 221 to 230 of about 150,436 (290)

Uncleaved signal peptide drives Golgi-bypassing secretion of the baculovirus fusion protein GP64. [PDF]

Microbiol Spectr
Zhu D, Hao Y, Zhang J, Xu Y, Hao B, Huang J.   +5 more
europepmc   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Cell death: immunogenic potential of cuproptosis in cancer. [PDF]

Signal Transduct Target Ther
Galluzzi L, Kepp O, Kroemer G.
europepmc   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

A multi-dimensional engineering strategy integrating computational design, self-cyclization and whole cell biocatalysis for efficient epilactose production. [PDF]

Food Chem X
Sun S, Liu J, Gao X, Jing D, Wang W, Yan Q, Shi S, Xiong P, Liu X.   +8 more
europepmc   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Sublethal Caspase-8 Activation Drives Radiation-Induced Genetic Instability and Oncogenic Transformation Through Endonuclease G and Non-Canonical NF-κB Signaling. [PDF]

Int J Mol Sci
Zhu C, Li X, Li CY, Liu R, Wang Y.
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

ACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m⁶A Modification to Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
Jia S, Gao X, Zhu L, Song H, Wu J, Chen S, Gao S, Zhang L, Meng C.   +8 more
europepmc   +1 more source

Time-resolved simultaneous imaging of mitochondrial reactive oxygen species and lysosomal permeabilization to determine organelle-centred cell death. [PDF]

Redox Rep
Jain Tiffee PJ, Sivasailam A, Kumar KS, Varghese Jancy S, Geetha Jayaprasad A, Halikar AM, Rather AA, Satheesan Sinivirgin N, Anurup KG, Santhoshkumar TR.   +9 more
europepmc   +1 more source