Results 201 to 210 of about 97,006 (262)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Decoding Cyclodextrins in Skin Applications: Structure, Mechanisms, and Safety in Cosmetic and Dermatologic Formulations (Part I). [PDF]

Int J Mol Sci
Mitrofan-Bandol DI, Nițu ET, Buliga L, Jîjie AR, Iftode OA, Ridichie A, Ledeți A, Ledeți I, Sbârcea L.   +8 more
europepmc   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Ionic-liquid-facilitated transdermal absorption of lidocaine hydrochloride. [PDF]

PLoS One
Ma X, Zhou Y, Jiang K, Wen Y.
europepmc   +1 more source

Transdermal Delivery of Sonidegib via Iontophoresis from PEDOT:PSS/Gelatin Hydrogels for Basal Cell Carcinoma Skin Cancer. [PDF]

Pharmaceutics
Sakunpongpitiporn P, Schwank J, Parinyanitikul N, Luangdilok S, Teeyapun N, Kesornsit A, Sirivat A.   +6 more
europepmc   +1 more source

Exploring the Interactions Between Methyl Methacrylate Polymers and the Bacterial Outer Membrane via Coarse-Grained Molecular Dynamics Simulations. [PDF]

J Chem Inf Model
Almeida ER, Firmino Dos Santos V, Ramstedt M, Soares TA.   +3 more
europepmc   +1 more source

Ex Vivo Buccal Permeability of Nanostructured Lipid Carriers (NLCs) Associated with a Peptide Drug Model. [PDF]

Pharmaceutics
Vargas-Valderrama S, Morales JO.
europepmc   +1 more source

Azelaic acid-integrated therapeutic deep eutectic systems: overcoming solubility and permeability barriers for enhanced transdermal drug delivery. [PDF]

RSC Adv
Du L, Wang S, Chen H, Liu C, Yang S, Wang Y, Cai B, Yang J, Ding Y.   +8 more
europepmc   +1 more source

Particle surface modification using isothermal dry coating to deliver biologics through the buccal route

Rajabi A, Tahan MAA, Iyire A, Wyatt D, Koner J, Mohammed AR.   +5 more
europepmc   +1 more source