Results 21 to 30 of about 41,464 (303)
Pharmaceutics, 2022 High-throughput permeation models are essential in drug development for timely screening of new drug and formulation candidates. Nevertheless, many current permeability assays fail to account for the presence of the gastrointestinal mucus layer.
Leah Wright +3 more
doaj +1 more source
Microneedle-Assisted Percutaneous Delivery of a Tetramethylpyrazine-Loaded Microemulsion
Molecules, 2017 This study examined the efficacy of the percutaneous delivery of a tetramethylpyrazine-loaded microemulsion (TMP-ME) on skin pretreated with microneedles (MN).
Qiang Zu +4 more
doaj +1 more source
Permeation of Dopamine Sulfate through the Blood-Brain Barrier. [PDF]
PLoS ONE, 2015 Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from peripheral sources.
Tina Suominen +2 more
doaj +1 more source
Systematic investigation of different formulations for drug delivery through the human nail plate "in vitro" [PDF]
, 2010 Human nails do not have only protective and decorative role, but can also be considered as an alternative pathway for drug delivery, especially in nail diseases such as onychomycosis or psoriasis.
Vejnoviċ, Ivana
core +1 more source
Nuclear Materials and Energy, 2016 Under tritium production method using a high-temperature gas-cooled reactor loaded Li compound, Li compound has to be coated by ceramic materials in order to suppress the spreading of tritium to the whole reactor. Pyrolytic carbon (PyC) is a candidate of
H. Ushida +6 more
doaj +1 more source
Entropic barrier of water permeation through single-file channels
Communications Chemistry, 2023 Facilitated water permeation through narrow biological channels is fundamental for all forms of life. Despite its significance in health and disease as well as for biotechnological applications, the energetics of water permeation are still elusive. Gibbs
Johann Wachlmayr +5 more
doaj +1 more source
An in vitro model for vitamin A transport across the human blood–brain barrier
eLife, 2023 Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem ...
Chandler B Est, Regina M Murphy
doaj +1 more source
Artificial tissue binding models : development and comparative evaluation of high - throughput lipophilicity assays and their use for PET tracer optimization [PDF]
, 2015 The purpose of this thesis was to increase the efficiency of the Positron Emission Tomography (PET) tracer development process. Since many neuroimaging agents fail due to undesirably high non-specific binding (NSB) to brain tissue, we aimed at estimating
Assmus, Frauke
core +1 more source
Pharmaceutics, 2023 The intranasal route of drug administration offers an opportunity to bypass the blood–brain barrier and deliver compounds directly into the brain. Scientific evidence exists for medicinal plants (e.g., Centella asiatica and Mesembryanthemum tortuosum) to
Anja Haasbroek-Pheiffer +4 more
doaj +1 more source
QSAR Studies on Blood-Brain Barrier Permeation
Current Computer Aided-Drug Design, 2006 Fil: Luco, Juan Maria. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia.
Luco, Juan Maria +1 more
openaire +2 more sources