Results 161 to 170 of about 5,572 (215)
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Permeation Enhancers for Transdermal Drug Delivery
Drug Development and Industrial Pharmacy, 2000The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance.
V R, Sinha, M P, Kaur
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Intestinal Permeation Enhancers
Journal of Pharmaceutical Sciences, 2000This review addresses the field of improving oral bioavailability through the use of excipients that increase intestinal membrane permeability. The critical issues to consider in evaluating these approaches are 1) the extent of bioavailability enhancement achieved, 2) the influence of formulation and physiological variables, 3) toxicity associated with
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Homoharringtonine is a transdermal granular permeation enhancer
Biochemical and Biophysical Research Communications, 2022Although modulation of claudin-1-based tight junction (TJ) in stratum granulosum is an option for transdermal absorption of drugs, granular permeation enhancers have never been developed. We previously found that homoharringtonine (HHT), a natural alkanoid, weakened intestinal epithelial barrier with changing expression and cellular localization of TJ ...
Akihiro, Watari +6 more
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Percutaneous permeation modifiers: enhancement versus retardation
Expert Opinion on Drug Delivery, 2008The use of permeation enhancers to compromise the barrier properties of skin has been ongoing for decades. However, toxicity associated with certain xenobiotics has led to the development of permeation retardants. Since both enhancers and retardants modify the surface layer of the skin, they can be collectively referred to as penetration modifiers.This
Diksha, Kaushik +4 more
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Mechanisms of oral permeation enhancement
International Journal of Pharmaceutics, 1997This paper reviews the effects of a diverse range of penetration enhancers, including fatty acids, bile salts, surfactants, Azone® and ethanol, on oral mucosa. We describe in detail the effects on the intercellular lipid domains, the changes induced in proteinaceous regions and potential interactions between the enhancer and endogenous structures along
Ganem-Quintanar, A. +3 more
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2016
Nanotechnology-based penetration enhancers provide novel mechanisms to improve current drug delivery methodologies. New developments in this field have been shown to overcome previous difficulties of ocular therapeutics like anatomical barriers and filtration mechanisms.
Nathaniel J. Kim +4 more
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Nanotechnology-based penetration enhancers provide novel mechanisms to improve current drug delivery methodologies. New developments in this field have been shown to overcome previous difficulties of ocular therapeutics like anatomical barriers and filtration mechanisms.
Nathaniel J. Kim +4 more
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Chemical permeation enhancers for transbuccal drug delivery
Expert Opinion on Drug Delivery, 2009The buccal drug delivery system has been accepted as a potential non-invasive route of drug administration, with the advantages of avoidance of the first-pass metabolism, sustained therapeutic action and better patient compliance. However, transmucosal delivery of drugs by means of the buccal route is still very challenging.
Nisreen, Hassan +3 more
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Self-Nanoemulsifying Electrospun Fiber Enhancing Drug Permeation
ACS Applied Materials & Interfaces, 2019Electrospun fibers are excellent drug carriers and tissue engineering scaffolds. However, approaches to promote drug permeation in tissues with such carriers remain of great interest. Here, we propose a Quality-by-Design strategy to enhance drug permeation with self-nanoemulsifying electrospun fibers.
Yi Xiang +5 more
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Mechanistic Studies of Permeation Enhancers
2005Effective methodologies are required for the mechanistic studies of chemical permeation enhancers in topical and transdermal drug delivery. Our previous studies have employed a systematic approach (a symmetric and equilibrium configuration) to study the mechanisms of action of chemical permeation enhancers for permeation across the lipoidal pathway of ...
William Higuchi, S Kevin Li
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