Results 171 to 180 of about 5,572 (215)

Amphiphilic Transdermal Permeation Enhancers: Structure-Activity Relationships

Current Medicinal Chemistry, 2005
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of this methodology. One of the approaches used to enlarge the number of transdermally-applicable drugs uses permeation enhancers.
K, Vávrová, J, Zbytovská, A, Hrabálek   +2 more
openaire   +2 more sources

Transdermal self-permeation enhancement of ibuprofen

Journal of Controlled Release, 2004
The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
openaire   +2 more sources

Amino acid derivatives as transdermal permeation enhancers

Journal of Controlled Release, 2013
Transdermal permeation enhancers are compounds that temporarily decrease skin barrier properties to promote drug flux. In this study, we investigated enhancers with amino acids (proline, sarcosine, alanine, β-alanine, and glycine) attached to hydrophobic chain(s) via a biodegradable ester link.
Barbora, Janůšová, Barbora, Skolová, Katarína, Tükörová, Lea, Wojnarová, Tomáš, Simůnek, Přemysl, Mladěnka, Tomáš, Filipský, Michal, Ríha, Jaroslav, Roh, Karel, Palát, Alexandr, Hrabálek, Kateřina, Vávrová   +11 more
openaire   +2 more sources

Effect of Permeation Enhancers on Buccal Absorption

Arzneimittelforschung, 2011
This paper reports an investigation on matrices based on the mucoadhesive polymers hydroxypropylmethylcellulose and sodium alginate, intended for sublingual administration of 1 mg lorazepam (LZ, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, CAS 846-49-1).
Susi, Burgalassi, Patrizia, Chetoni, Laura, Dini, Marcela, Najarro, Daniela, Monti, Paolo, Morelli, M Fabrizio, Saettone   +6 more
openaire   +2 more sources

Polymeric Permeation Enhancers

2009
There are enough low molecular permeation enhancers available to increase the absorption of hydrophilic drugs, but all of them have the disadvantage of strongly interfering with the phospholipid membranes and of damaging them. Polymeric permeation enhancers are a class of substances which are able to selectively trigger mechanisms to selectively open ...
openaire   +1 more source

Effects of Adhesives and Permeation Enhancers on the Skin Permeation of Captopril

Drug Development and Industrial Pharmacy, 2001
To formulate a transdermal drug delivery system of captopril, monolithic adhesive matrix type patches containing 20% captopril, different pressure-sensitive adhesives, and various permeation enhancers were prepared using a labcoater. The effects of the adhesives and permeation enhancers on skin permeation of captopril from the prepared patches were ...
E S, Park, S J, Chang, Y S, Rhee, S C, Chi   +3 more
openaire   +2 more sources

Enhanced insulin absorption from sublingual microemulsions: effect of permeation enhancers

Drug Delivery and Translational Research, 2014
Microemulsions of insulin (50 IU/mL) comprising permeation enhancers were formulated for sublingual delivery. Circular dichroism (CD) spectra indicated conformational stability, while chemical stability was confirmed by high-performance liquid chromatography (HPLC).
Nilam H, Patil, Padma V, Devarajan
openaire   +2 more sources

[Influence of permeation enhancers on transdermal permeation of anemonin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning, Yue-Feng, Rao, Wen-Quan, Liang   +2 more
openaire   +1 more source

Effect of Iontophoresis and Permeation Enhancers on the Permeation of an Acyclovir Gel

Current Drug Delivery, 2010
The purpose of the present study was to explore the combined effect of chemical enhancers and iontophoresis on the in vitro permeation of acyclovir gel across porcine skin. Acyclovir gel was formulated using carbopol 940 and hydroxypropyl methylcellulose K4M (HPMC K4M). Effect of drug concentration on the delivery of acyclovir was examined.
Subhash S, Vaghani, Mitesh, Gurjar, Sachin, Singh, Sunil, Sureja, Shailesh, Koradia, N P, Jivani, M M, Patel   +6 more
openaire   +2 more sources

Effect of permeation enhancers and organic acids on the skin permeation of indapamide

International Journal of Pharmaceutics, 2008
The aim of present study was to investigate the transdermal properties of indapamide and to explore the efficacy of various permeation enhancers and organic acids with regard to the percutaneous absorption of indapamide. Permeation experiments were performed in vitro, using rat abdominal skin as a barrier. In the permeation studies, 2-chamber diffusion
Changshun, Ren, Liang, Fang, Ting, Li, Manli, Wang, Ligang, Zhao, Zhonggui, He   +5 more
openaire   +2 more sources