Results 91 to 100 of about 448,945 (257)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Evaluation of Heavy Metals Level and their Potential Effects to Water, Sediment, and Water Hyacinth Plants in Opa Reservoir, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria

Journal of Applied Sciences and Environmental Management
The contamination of the aquatic ecosystem with heavy metals has become a rising global concern due to their possible adverse health effects on human beings and the environment.
K. T. Ogundele, O. W. Makinde, E. A. Oluyemi, A. S. Kayode, S. O. Afolabi, O. A. Omisore   +5 more
doaj  

Valorisation of brewery spent grain for biogas production and nutrient-enriched bioslurry in sustainable agriculture

International Journal of Sustainable Energy
This study assesses brewery spent grain (BSG) from Dashen Brewery Gondar, Ethiopia, as a locally available and renewable substrate for biogas and nutrient-rich bioslurry production.
Tewodros Mulu, Bilhate Chala, Yezbie Kassa, Bernhard Freyer, Tarekegne Fentie, Marye Mulugeta, Dessie Tibebe   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Peptidomics of salivary histatins: enrichment strategy and de-novo sequencing

, 2016
Peptidomics of salivary histatins: enrichment strategy and de-novo ...
V Marzano, M Castagnola, D Delfino, I Messana, S Della Vecchia, F Iavarone, A Vitali, T Cabras   +7 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Thirty years later: Enrichment practices for captive mammals

, 2009
Environmental enrichment of captive mammals has been steadily evolving over the past thirty years. For this process to continue, it is first necessary to define current enrichment practices and then identify the factors that limit enhancing the quality ...
Peter J. Murray, Hoy, Julia M., Tribe, Andrew, Julia M. Hoy, Murray, Peter J., Andrew Tribe   +5 more
core   +1 more source

Environmental Enrichment for Primates in Laboratories [PDF]

, 2010
Environmental enrichment is a critical component of Refinement, one of the 3Rs underlying humane experimentation on animals. In this paper I discuss why primates housed in laboratories, which often have constraints of space and study protocols, are a ...
H. M. Buchanan-Smith, Buchanan-Smith, Hannah M   +1 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source