Results 101 to 110 of about 448,945 (257)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Assessment of heavy metal content in urban agricultural soils

Nucleus, 2015
Concentrations of Cr, Co, Ni, Cu, Zn and Pb in the topsoils (0–10 cm) from ten farms located in the vicinity of a steel-smelter plant at Cotorro (Havana, Cuba) were measured by X-ray fluorescence analysis.
Oscar Díaz Rizo, Lázaro Lima Cazorla, Damaris García Céspedes, Katia D´Alessandro Rodríguez, Oscar Torres Leyva   +4 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Trophic transfer of arsenic in the food chain from selected crops grown in long-term wastewater contaminated soil

Agricultural Water Management
Arsenic (As) contamination is a major health problem that exists worldwide. The accumulation of toxic metals in the surrounding soils of advanced industrial and agricultural sectors has the potential to degrade the ecosystem.
Mudasra Munir, Kafeel Ahmad, Zafar Iqbal Khan, Shahzad Akhtar, Muhammad Nadeem, Asma Ashfaq, Mohammad Faisal, Abdulrahman A. Alatar, Hafiza Mamona Nazir, Ifra Saleem Malik   +9 more
doaj   +1 more source

Main numerations of computable functionals on permissible sets

, 1992
Permissible sets are studied. The work is aimed at demonstration of sufficient conditions of existence of main numerations of computable functionals on permissible sets.
Vytsenavichus Rimantas Yuosas Vitautovich
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Control over Permissible Short Emergency Overloads in Power Transformers

, 2010
The paper proposes a method for determination a permissible duration of short intermittent overloads of power transformers that permits to avoid non-permissible over-heating of winding insulation and fully utilize overloading transformer ...
V. A. Adamtsevich, V. A. Anischenko
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Co-occurrence, sources and co-enrichment mechanism of arsenic, fluoride in groundwater from Huaihe River Basin, China

Emerging Contaminants
Arsenic (As), fluoride (F−) are both ubiquitous in groundwater, and co-exposure to these elements through contaminated drinking water may cause detrimental effects on human health more in comparison with individual exposure.
Naizheng Xu, Lin Liu, Tan Mengjiao, Xiaohu Tao, Liang Li, Hesheng Wang, Jianshi Gong   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source