Results 71 to 80 of about 594,037 (266)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Humaniora, 2011 As a country that respects the rule of law, permission can be a commodity as the establishment of a policy creation rules or derivation of state law dogma. The subject of law could not be carelessly with the presence of policies and regulations.
Iron Sarira
doaj
Preparation of Ethic codes for studies on laboratory animals
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006 In most of research programs, uses of laboratory animals are necessary. For this reason we have to prepare comfortable and health situation near their natural life for animals in laboratory.
SJ Ale davoud +6 more
doaj
Formalizing Permission to Delegate and Delegation with Policy Interaction
SensorsIn the context of Internet of Things (IoT) intelligent systems, the latest research regarding delegation using an access control model has gained attention, reflecting the need for models to support more functionalities in relation to hierarchical ...
Azan Hamad Alkhorem +3 more
doaj +1 more source
Permissive Metaepistemology [PDF]
Mind, 2018 AbstractRecent objections to epistemic permissivism have a metaepistemic flavor. Impermissivists argue that their view best accounts for connections between rationality, planning and deference. Impermissivism is also taken to best explain the value of rational belief and normative assessment.
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Èkonomika, Pedagogika i Pravo, 2016 In this article author takes up questions of qualification of the organization and carrying out gamblings in a gambling zone based on the permission got illegally which are treated as illegal business activity.
Boris R. Avetisyan
doaj
ComputersAuthentication is essential to hold users accountable across online services. Conventional authentication systems rely on centralized architectures or third-party identity providers, which, however, introduce single points of failure, privacy concerns ...
Valerio Mandarino +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source