Results 111 to 120 of about 141,402 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On characterizing pairs of permutations in determining their generated group [PDF]
, 2013 Among the unsolved problems in mathematics listed on Wolfram Mathworld's website is finding a formula for the probability that two permutations chosen at random generate the symmetric group.
Watts, Michael D. +1 more
core
Random partitions in statistical mechanics [PDF]
, 2014 We consider a family of distributions on spatial random partitions that provide a coupling between different models of interest: the ideal Bose gas; the zero-range process; particle clustering; and spatial permutations.
Nicholas Ercolani (16242443) +8 more
core +1 more source
Generation of cycle permutation graphs and permutation snarks
Mathematics of ComputationWe present an algorithm for the efficient generation of all pairwise non-isomorphic cycle permutation graphs, i.e. cubic graphs with a $2$-factor consisting of two chordless cycles, non-hamiltonian cycle permutation graphs and permutation snarks, i.e. cycle permutation graphs that do not admit a $3$-edge-colouring.
Jan Goedgebeur +2 more
openaire +3 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Permutation and local permutation polynomials of maximum degree
Afrika MatematikaAbstract Let $$\mathbb {F}_q$$ F q be the finite field with q elements and $$\mathbb {F}_q[x_1,\ldots , x_n]$$
Gutierrez Gutierrez, Jaime +1 more
openaire +6 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Counting permutations where the difference between entries located r places apart can never be s (for any given positive integers r and s) [PDF]
Enumerative Combinatorics and Applications, 2023 George Spahn, Doron Zeilberger
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source