Results 91 to 100 of about 115,299 (267)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
ADAPTIVE REORDERING OF OBSERVATION SPACE TO IMPROVE PATTERN RECOGNITION
TASK Quarterly, 2007 The problem of observation space reordering is presented as a novel approach to pattern recognition based on non-parametric, combinatorial statistical tests. It consists in linearly ordering the elements of a discrete multi-dimensional observation space
JULIUSZ L. KULIKOWSKI
doaj
Log-Convexity and Fixed Points of Permutations
AxiomsWe provide a combinatorial proof for the fact that the numbers of derangements of length n form a log-convex sequence for n≥3. A minor modification of our proof yields the same result for permutations of length n≥4 that have exactly one fixed point.
Miklós Bóna
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Permutation statistics of products of random permutations
Advances in Applied Mathematics, 2014 Given a permutation statistic $s : S_n \to \mathbb{R}$, define the mean statistic $\bar{s}$ as the statistic which computes the mean of $s$ over conjugacy classes. We describe a way to calculate the expected value of $s$ on a product of $t$ independently chosen elements from the uniform distribution on a union of conjugacy classes $Γ\subseteq S_n$.
openaire +3 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The shallow permutations are the unlinked permutations
, 2022 Diaconis and Graham studied a measure of distance from the identity in the symmetric group called total displacement and showed that it is bounded below by the sum of length and reflection length. They asked for a characterization of the permutations where this bound is an equality; we call these the shallow permutations.
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source