Results 131 to 140 of about 476,988 (354)

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha   +6 more
wiley   +1 more source

The bireflections of a permutation

open access: yesDiscrete Mathematics, 1976
AbstractA bireflection of a permutation θ is an ordered pair (φ, ψ) of permutations satisfying φ2 = ψ2 = 1, θ = φψ. The family of bireflections of a permutation is studied. As a corollary an expression for the number of dihedral groups over θ in SA is obtained.
openaire   +2 more sources

Cayley permutations

open access: yesDiscrete Mathematics, 1984
AbstractA Cayley permutation (C-permutation for short) of length n is a permutation p of n elements with possible repetitions from a set {a1, …, an} of n elements with an order relation, subject to the condition that if an element ai appears in p, then all elements ai < ai also appear in p.
A.S Fraenkel, M Mor
openaire   +2 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

open access: yesMolecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou   +11 more
wiley   +1 more source

On Permutations and Permutation Polytopes [PDF]

open access: yes, 1978
Permutation polytopes arise in a class of problems in which the objective is to find an optimal complete ordering of some given alternatives, subject to a linear objective criterion. In this paper an easy characterization is given of neighbors on permutation polytopes.
openaire   +4 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Basic combinatorial configurations in preschool teacher education [PDF]

open access: yesSinteze, 2013
The paper presents arguments for the need for combinatorial education of preschool teachers. To this effect, the author presents the minimal content which such training should cover in his opinion.
Živanović Milan V., Pikula Milenko T.
doaj  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

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